Infectious Diseases and Health Access among Migrants in Cambodia – Final Report

Attachments A steady economic growth over the last two decades in Cambodia and the ASEAN region has contributed to an increase in internal and international migration in search of better employment and livelihood opportunities. Migrants and mobile populations (MMP) face many obstacles in accessing essential health-care services due to a number of factors, including irregular migratory status, language barriers, a lack of migrant-inclusive health policies and inaccessibility of realization of global health goals, such as preventing HIV, containing tuberculosis the human influenza pandemics, and other key infectious diseases. High morbidity and mortality among migrants, especially in irregular, force, or exploitative migration situations is an underestimated critical health concern that deserves international attention. The research study undertaken by IOM aimed to analyse migrants’ knowledge on six infectious diseases (HIV/AIDS, tuberculosis, Hepatitis B, Hepatitis C, dengue fever and malaria) and any barriers which may prevent them from accessing health services. The report covers findings from a data collection study in five provinces linking Cambodia to Thailand, Viet Nam and Lao People’s Democratic Republic where migrant populations live. It also provides wide-ranging recommendations for the government institutions, development sector and local authorities on increasing the migrants’ populations understanding of disease prevention.

Bleeding Out: ‘We want people to live’: How San Antonio is trying to prevent deaths from blood loss

By Lauren Caruba | Investigative Reporter Published Nov. 29, 2023 SAN ANTONIO — The way Dr. Donald Jenkins sees it, what saves lives on the battlefield could save lives on streets across America. During nearly 25 years in the Air Force, Jenkins operated on troops with devastating wounds from bombs and bullets — ones not so different than those that ordinary people sustain from cars, gun violence and random accidents. Injuries he saw from rollover crashes in combat zones are similar to those from high-speed highway wrecks. Gunfire tears through tissues and vital organs the same if it comes from an enemy combatant or a licensed gun owner. From his deployments, Jenkins knew that a single factor — bleeding, and how well it was controlled before patients landed on his operating table — dictated survival. Those who received blood quickly, especially on the way to the hospital, were more likely to remain stable during surgery and recover. Without it, death could come in a matter of minutes. The same is true for everyday Americans, who regularly bleed to death before doctors can repair their injuries. But unlike in combat zones, where military medics usually have blood on hand, in the U.S. there haven’t been any broad or comprehensive efforts to give blood to hemorrhaging patients before they arrive at a hospital. The best most paramedics can offer their patients is saline and medications that slow bleeding. Why not treat them the same, Jenkins wondered years ago, after he left the military and began a new medical career as a civilian. If patients needed blood when they arrived at the hospital, surely they needed it before then, too. Why not give patients blood as soon as possible, when they need it most? Five years ago, in San Antonio, a city with strong military ties, Jenkins finally got the chance to test his idea to put blood on ambulances and helicopters across the region. Today, Jenkins’ theory has turned into one of the country’s most innovative and pioneering models of advanced care, an example of how access to blood soon after a traumatic incident can save lives, some of the nation’s leading trauma researchers say. Across the U.S., a growing number of EMS providers have replicated parts of San Antonio’s blood program, helping critically injured patients in cities like Austin, New Orleans, Seattle, Oklahoma City and Pittsburgh and in South Florida — often with advice from San Antonio’s trauma leaders. “We have very openly exported all of our ideas, our protocols and our data,” said Jenkins, a trauma surgeon with UT Health San Antonio and University Hospital. “We’re not looking for a patent. We’re not looking to make money off of this. We just want to see people live.” Since the South Texas program’s start in 2018, more than 2,100 patients have received blood transfusions on the way to a hospital. Many were car crash and shooting victims, including a 37-year-old mother of two in San Antonio who was clinically dead after a car crash when blood revived her. There were also patients bleeding from pregnancy complications and other medical problems. We’re not looking for a patent. We’re not looking to make money off of this. We just want to see people live.” Dr. Donald Jenkins Early research from the program has found trauma patients who received transfusions before reaching a hospital were more likely to survive the immediate aftermath of their injury, which medical experts consider to be the most critical period. Longer term survival rates remain the subject of study. Already, there have been remarkable success stories, lives that likely would have otherwise been lost, according to the paramedics who treated them. They include a South Texas man who severed arteries in his arm while working with a tool at home and an oil field worker in his early 20s who suffered a partial leg amputation while working with a malfunctioning drill. “We’re providing the patients with what they need, when and where they need it,” Jenkins said. Every day, trauma physicians and paramedics confront a deadly public health crisis. Traumatic injury is a major cause of premature death, killing around 150,000 Americans each year, including more children and adults under age 45 than any other cause. In 2021, Texas led the nation in deaths from motor vehicle crashes and guns, federal data shows. A yearslong investigation by The Dallas Morning News and the San Antonio Express-News has found tens of thousands of these injured patients are dying from wounds they could have survived had they received crucial treatments sooner. Some of the nation’s most respected researchers estimate that, each year, 31,000 Americans bleed to death from survivable injuries, with lifesaving transfusions usually out of reach until patients arrive at a hospital. In more than 140 interviews, the news organizations found paramedics are unequipped to fully treat severe internal bleeding and patients receive drastically different care depending on where they are injured. After decades of inadequate federal funding for research and little attention by elected officials, outcomes for these patients remain poor and have stagnated over the past decade, the investigation found. Federal officials have failed to adopt major reforms that could save lives, even after being confronted in 2016 with growing evidence that large numbers of injured patients are needlessly dying every day. ‘Liquid gold’ The idea for San Antonio’s blood program began in a war zone in October 2001, on Masirah Island off the coast of Oman. There, Jenkins was the first surgeon to enter the combat zone, standing by as special forces parachuted into southern Afghanistan. Over the next two weeks, he treated dozens of injured troops. Back home, hospitals had stockpiles of dozens of blood components — oxygen-carrying red blood cells, circulation-promoting plasma and clot-facilitating platelets. Jenkins and the military medical team made do with what they had, tapping service members to give blood. When he gave this fresh blood to wounded troops, he was stunned by how quickly it worked. Before his eyes, they

Aids Commission warns of HIV infection ahead of festive season

Dr Nelson Musoba, the director general of Uganda Aids Commission, has urged nationals to be cautious of the risk of HIV infection as they head for festive season. “When you are excited, when you take alcohol, your judgement is impaired and when you meet new people, there is risk [of contracting HIV], so you have to plan for it. Let the young people who are not of age take precaution and abstain. Let the adults protect themselves and protect each other, let them use protection if they must have sex. Know the [HIV] status of your partners,” he said. Addressing journalists in Kampala yesterday, Dr Musoba said HIV infections are still high in the country with around 1,000 people contracting the virus every week. He said this while announcing the World Aids Day commemorations on December 1, which will be held in Rakai District with President Museveni expected to be the chief guest. According to the statistics from the Commission, more than 51,000 people contracted HIV last year and out of more than 1.4 million people living with the virus, around 17,000 died. The figures indicate that new infections are higher among adolescents and young women. Ms Jacqueline Makokha, the country director of The Joint United Nations Programme on HIV/Aids (UNAids), also told journalists that this year’s commemoration will be held under the theme: “Let communities lead.” “Communities connect people with person-centered public health services, they build trust, they innovate, they monitor implementation of policies and services and they hold service providers accountable. Globally, communities are being held back and are struggling. They are facing funding shortages, policy and regulatory hurdles, capacity constraints and crackdown on some community groups,” she said. Dr Stephen Watiti, the outgoing chairperson of the National Forum of People Living with HIV/Aids Networks in Uganda, appealed to persons living with HIV to adhere to their medication and not spread the infection to other people. “We know what to do, we can stop it [HIV infections and deaths]. The few of us who are infected should combine efforts to ensure that we are not dying by adhering to medication while we are also not infecting others,” he said. Ms Ruth Awori, the executive director of Uganda Network of Young People Living with HIV/Aids (UNYPA), asked the government to increase interventions that focus on reducing infections among adolescent girls and women. She also appealed for increased local funding towards HIV/Aids to ensure sustainability as donors warned of dwindling funding. “HIV is a big problem among children and the youth and this is because of various reasons such as mother to child transmission because of the challenges mothers face despite availability of medical intervention, which see them still transmitting the virus. When this happens, we need to support the children to ensure they adhere to the treatment and live productive life,” she said, adding that many young people are also contracting HIV through unprotected sex.

Thalidomide: Australia gives national apology to survivors and families

Developed in Germany in the 1950s, thalidomide was originally used as a sedative or tranquiliser, but soon became widely promoted around the world as a morning sickness drug. As usage increased, so too did reports of birth defects – usually in the form of significantly shortened limbs. It was an Australian report in The Lancet medical journal that first warned the world of thalidomide’s dangers in 1961, and it was taken off the market soon after. By then an estimated 10,000 babies globally had been born with disabilities. For decades, survivors have fought for acknowledgments of wrongdoing and compensation. Canada introduced financial assistance for survivors in 1991, and in 2010 the UK issued a national apology to those affected. But it wasn’t until a landmark Senate inquiry in 2019 that Australia took action to support survivors. Its financial scheme provided a one-off payment of up to A$500,000 ($332,000; £261,000) to survivors, followed by annual payments of between A$5,000 and A$60,000. The programme was later closed to new applicants, but on Wednesday Mr Albanese reopened it “to ensure that anyone who may have missed the previous opportunity to apply does not miss out”. In East Germany, thalidomide was rejected by the Central Committee of Experts for the Drug Traffic in the GDR, and was never approved for use. There are no known thalidomide babies born in East Germany. Meanwhile, in West Germany, it took some time before the increase in dysmelia at the end of the 1950s was connected with thalidomide. In 1958, Karl Beck, a former pediatric doctor in Bayreuth, wrote an article in a local newspaper claiming a relationship between nuclear weapons testing and cases of dysmelia in children. Based on this, FDP whip Erich Mende requested an official statement from the federal government.[ For statistical reasons, the main data series used to research dysmelia cases started by chance at the same time as the approval date for thalidomide. After the Nazi regime with its Law for the Prevention of Hereditarily Diseased Offspring used mandatory statistical monitoring to commit various crimes, western Germany had been very reluctant to monitor congenital disorders in a similarly strict way. The parliamentary report rejected any relation with radioactivity and the abnormal increase of dysmelia. Also the DFG research project installed after the Mende request was not helpful. The project was led by pathologist Franz Büchner, who ran the project to propagate his teratological theory. Büchner saw lack of healthy nutrition and behavior of the mothers as being more important than genetic reasons. Furthermore, it took a while to appoint a Surgeon General in Germany; the Federal Ministry of Health was not founded until 1962, some months after thalidomide was banned from the market. In West Germany approximately 2,500 babies were born with birth defects from thalidomide. In the U.S., the FDA refused approval to market thalidomide, saying further studies were needed. ‘This reduced the impact of thalidomide in U.S. patients. The refusal was largely due to pharmacologist Frances Oldham Kelsey who withstood pressure from the Richardson-Merrell Pharmaceuticals Co. Although thalidomide was not approved for sale in the United States at the time, over 2.5 million tablets had been distributed to over 1,000 physicians during a clinical testing programme. It is estimated that nearly 20,000 patients, several hundred of whom were pregnant women, were given the drug to help alleviate morning sickness or as a sedative, and at least 17 children were consequently born in the United States with thalidomide-associated deformities. While pregnant, children’s television host Sherri Finkbine took thalidomide that her husband had purchased over-the-counter in Europe. When she learned that thalidomide was causing fetal deformities she wanted to abort her pregnancy, but the laws of Arizona allowed abortion only if the mother’s life was in danger. Finkbine traveled to Sweden to have the abortion. Thalidomide was found to have deformed the fetus. For denying the application despite the pressure from Richardson-Merrell Pharmaceuticals Co., Kelsey eventually received the President’s Award for Distinguished Federal Civilian Service at a 1962 ceremony with President John F. Kennedy. In September 2010, the FDA honored Kelsey with the first Kelsey award, given annually to an FDA staff member. This came 50 years after Kelsey, then a new medical officer at the agency, first reviewed the application from the William S. Merrell Pharmaceuticals Company of Cincinnati. Cardiologist Helen B. Taussig learned of the damaging effects of the drug thalidomide on newborns and in 1967, testified before Congress on this matter after a trip to Germany where she worked with infants with phocomelia (severe limb deformities). As a result of her efforts, thalidomide was banned in the United States and Europe.

Blood cancer treatment may cause cancer

GREEN BAY, Wis. (WBAY) – A life-saving cancer treatment may sometimes cause cancer. The FDA is investigating right now, saying it received 19 reports of new blood cancers in patients who received the CAR-T cancer treatment. CAR-T is short of Chimeric Antigen Receptors and the T-cells in your blood. CAR-T therapy was first approved in 2017 and involves removing a type of white blood cell from a patient’s blood. It’s also used when patients have already had at least one round of conventional treatment with intense chemotherapy and radiation. The FDA says patients who received this therapy should be monitored for new malignancies for the rest of their lives. Cancer specialists say CAR-T treatments have saved the lives of thousands of patients with blood cancers and the benefits outweigh the risk. The FDA says patients and health care providers who have questions can give the agency a call. Copyright 2023 WBAY. All rights reserved.

People using ADHD medicines for a long time may have higher risk of cardiovascular diseases

A large proportion of patients who start taking ADHD medication, especially young adults, stop within the first year. However, people who use ADHD medicine for a long time and in higher-than-average doses seem to have a higher risk of some cardiovascular diseases. This is according to two new studies led by researchers from Karolinska Institutet and published in The Lancet Psychiatry and JAMA Psychiatry. More than half of all teenagers, young adults and adults who received ADHD medication had stopped taking it within the first year. The proportion of children, on whose behalf decisions are made by parents or guardians, was slightly lower, but nonetheless, 35 per cent stopped their medication within a year. So reports a multinational study led by researchers at Karolinska Institutet in Sweden and published in The Lancet Psychiatry. Risk falling between the cracks The researchers analysed prescription data from over 1.2 million patients who started ADHD medication in Australia, Denmark, Hong Kong, Iceland, the Netherlands, Norway, the UK, Sweden and the USA. The pattern was the same in all countries/regions. “It’s unlikely that so many people discontinue their treatment because their ADHD symptoms have remitted, meaning that the high rate of early discontinuation may be a major barrier to effective treatment,” says Zheng Chang, senior researcher at the Department of Medical Epidemiology and Biostatistics at Karolinska Institutet who led both studies. “We haven’t been able to analyse the direct causes in this study, but common reasons for discontinuing ADHD medication are adverse reactions and lack of effect.” The highest rate of medication discontinuation occurred among 18 to 19-year-olds. This is when they leave child and adolescent psychiatry and enter adult psychiatry, a transition where they risk falling between the cracks. This is a shortcoming that the healthcare services must remedy, researchers say. “We need to improve the transition to adult psychiatry and spread knowledge about the fact that problems associated with ADHD often persist over time,” says Isabell Brikell, research coordinator at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, and one of the first authors of the study in The Lancet Psychiatry. “In addition, new digital tools such as simple SMS-based inventions could be used to help people with ADHD manage their medication.” Denmark sticks out A country that sticks out in the statistics is Denmark, which had a much lower proportion of children who discontinue their treatment within a year – 18 per cent, as opposed to the mean of 35 per cent. Compared with other Nordic countries like Sweden and Norway, the prescription of ADHD drugs is lower, which could suggest that medication is only prescribed to those with severe ADHD and the greatest need, researchers say. Sweden has a relatively high prescription rate of ADHD medication compared with many other European countries, so it is possible that we over-prescribe here.” Zheng Chang, senior researcher at the Department of Medical Epidemiology and Biostatistics at Karolinska Institutet Related Stories In another study conducted with over 275,000 Swedish ADHD patients published in JAMA Psychiatry, Dr Chang and his research group examined ADHD medication use for up to 14 years. They were then able to show that ADHD medication when taken for a longer time and in higher doses than average is associated with a higher risk of some cardiovascular diseases, primarily hypertension and arterial disease. In general, the risk of cardiovascular disease increased by approximately four per cent annually. The risk increase was greatest in the first few years of treatment and then levelled off, and it was only statistically significant at doses higher than 1.5 times the average daily dose (so-called defined daily dose, DDD). This means that those treated with lower doses are not likely to develop cardiovascular disease, according to the researchers. Patients should be followed up “There is a long list of drugs that have been linked to a comparable increased risk of hypertension when used long-term such as the one found here, so patients should not be alarmed by these findings,” says Le Zhang, postdoc researcher in Dr Chang’s research group and first author of the JAMA Psychiatry study. “However, in clinical practice, the raised risk should be carefully weighed against the recognised benefits of treatment on a case-by-case basis. Doctors should also regularly follow up the ADHD patients to find signs and symptoms of cardiovascular disease while they’re on medication over the long-term.” Since this is an observational study, it is not possible to conclude that it is the ADHD medication that leads to an increased risk of cardiovascular disease. As the researchers point out, it could depend on other medications, symptom severity or lifestyle factors. The studies were financed by the EU’s Horizon 2020 Research and Innovation Programme and Forte (the Swedish Research Council for Health, Working Life and Welfare). Some of the coauthors have potential conflicts of interest to declare, see the scientific articles for more information. Karolinska Institutet Journal references: Brikell, I., et al. (2023). ADHD medication discontinuation and persistence across the lifespan: a retrospective observational study using population-based databases. The Lancet Psychiatry. doi.org/10.1016/s2215-0366(23)00332-2. Zhang, L., et al. (2023). Attention-Deficit/Hyperactivity Disorder Medications and Long-Term Risk of Cardiovascular Diseases. JAMA Psychiatry. doi.org/10.1001/jamapsychiatry.2023.4294.

Mycoplasma pneumoniae: une “recrudescence inhabituelle” d’infections respiratoires confirmée

Selon la Direction générale de la Santé (DGS), des “cas nécessitant une hospitalisation chez les adultes et les enfants en France” ont été recensés. Dans un message adressé ce mercredi 29 novembre aux professionnels de la santé, la Direction générale de la santé (DGS) a alerté d’une “recrudescence inhabituelle” de cas d’infections respiratoires à Mycoplasma pneumoniae, “y compris de cas nécessitant une hospitalisation chez les adultes et les enfants en France.” Cette bactérie dite “atypique” faisait déjà l’objet d’une surveillance spécifique après que SOS Médecins a informé d’une hausse des infections pulmonaires chez les enfants à la fin novembre, en particulier chez les 6 à 15 ans. Selon la DGS, la Mycoplasma pneumoniae est responsable d’infections respiratoires, très fréquentes chez les enfants de plus de 4 ans et les jeunes adultes, qui sont dans l’immense majorité bénignes et guérissent spontanément. “La transmission interhumaine se fait via les gouttelettes et l’incubation est de 1 à 3 semaines”, apprend-on encore. “Six mois de stocks” d’antibiotiques Face à cette augmentation des cas, la DGS dit poursuivre “ses analyses au niveau national afin de préciser les caractéristiques et la dynamique actuelle de l’épidémie”, et appelle également l’Agence nationale de sécurité du médicament (ANSM) à “un suivi renforcé de la consommation des antibiotiques utilisés en période hivernale.” Interrogé ce mercredi matin à ce sujet sur l’antenne de Franceinfo, le ministre de la Santé, Aurélien Rousseau, a assuré qu’il s’agit d’une “bactérie” que l’on “connaît bien”, et a évoqué une augmentation “comme dans tous les pays d’Europe.” “On a six mois de stocks” d’antibiotiques pour traiter d’éventuels malades en France, a-t-il assuré.

Callaway County Extended Employment to host blood drive

The Callaway County Extended Employment Center is partnering with the American Red Cross to host a blood drive on Monday. Marla Mason, general manager at the Callaway County Extended Employment Center, said appointments to donate blood can be reserved online. Walk-in appointments will also be accommodated. Appointments for regular blood donation and Power Red donation are available. Blood donors will receive a free t-shirt and a $10 Amazon gift card, Mason said. The blood drive will be 10 a.m. to 2 p.m. Dec. 4 at the Callaway County Extended Employment Center, 2611 N. Bluff St. in Fulton. To reserve an appointment to donate blood, visit https://www.redcrossblood.org/give.html/find-drive.

Israel clearly learnt nothing from France’s blood-soaked occupation of Algeria

It was sheer barbarism and savagery that brought an end to France’s brutal 132-year-long occupation of Algeria, and it is the same destructive force that will end Israel’s war against the Palestinians in Gaza. At the moment, though, it is clear that Israel has learnt nothing from France’s blood-soaked occupation of Algeria. Like the ongoing fight for the liberation of Palestine from Zionist rule, history still has much to write about the atrocities committed by French colonialists in Algeria during the occupation from 1830 to 1962. At least five million people were killed and hundreds of thousands were wounded in the struggle for independence. In 1959, French President Charles de Gaulle declared that the Algerians had the right to determine their own future. Despite so-called terrorist acts by French Algerians opposed to independence and an attempted coup in France by elements of the French army, an agreement was signed in 1962, and Algeria was finally independent. Algeria is still known as the Land of a Million Martyrs, a figure far too conservative, according to those who live in Africa’s largest country today. As for France, it has learned little or nothing from its legacy as a brutal occupier and the terrorism that its occupation of Algeria fostered. READ: Erdogan tells UN chief that Israel must face international courts over Gaza crimes I now wonder if Gaza has reached its “Algeria moment” in a 75-year conflict which ultimately created the conditions for the 7 October attack against the brutal and rapacious Zionist occupation state. The scale of the attack has traumatised Israel and many within the Jewish diaspora. The ferocity with which the Hamas-led resistance fighters hit back has destroyed the arrogance and confidence of the Zionist State and its supporters in the same way that 9/11 knocked the stuffing out of the American swagger. Sadly, neither the US nor Israel took the time to catch their breath and ask why these events happened. The question was never asked and America’s response, as Israel’s will, went on to radicalise a generation of young people around the world. The so-called “War on Terror” crushed any semblance of respect for human rights, international law and the Geneva and Vienna conventions. Officially-sanctioned kidnapping and torture gave us the new 21st century euphemisms of “extraordinary rendition” and “enhanced interrogation techniques”. To their eternal shame, European countries looked the other way as the US intelligence agencies installed black sites for ghost detainees and tortured them on an industrial scale. US President George W Bush probably had no idea that he was about to embark on America’s longest ever war in his blind fury to get revenge by attacking the Taliban regime in Afghanistan, which, incidentally, played no part in 9/11. Twenty years and four presidents later, the war ended as spectacularly as it had started, when the biggest and most powerful army in the world fled, Vietnam style, and the Taliban returned to power in Kabul. READ: Aid entering Gaza is 5% of what entered before 7 October There are fears that Israel has been lured into a similar trap by Hamas, which is believed to have invested two years in planning the attack on the apartheid occupation state. The raging fury which erupted in Tel Aviv on 7 October was entirely predictable and probably had a lot to do with the catastrophic intelligence failure by the Israeli military which was caught napping by the audacious, daring breakout from the Gaza concentration camp by Hamas fighters belonging to the movement’s military wing, Al-Qassam Brigades. Israeli Prime Minister Benjamin Netanyahu was seen strutting around in his army fatigues like some aging Volodymyr Zelenskyy, threatening revenge of Biblical proportions on the Palestinian people. At times he still seems confused about who he is waging his bitter, vindictive war against: Palestine, its women and children, or Hamas; or all of them. One unhelpful government minister expressed the desire to “nuke” Gaza — he let the cat out of the bag and basically confirmed that Israel has nuclear weapons — so it’s little wonder that no one is focused on an end game. We need to know who will govern Gaza after the war and how it will be governed. This should be decided by the people of Palestine, not corrupt politicians in Israel and the West. World leaders have been bullied into silence while Israel commits war crimes as a matter of routine, bombing hospitals, UN schools and civilian infrastructure, and cutting off all water and power supplies to the civilian population. Thank God Queen Rania of Jordan stood up and spoke out for the Palestinian people; she exposed the “strongmen” across the Arab world as the cowards that they are. The cack-handed Americans took “shock and awe” to Iraq, leaving us incredulous that no one seemed to have given any thought to what was going to happen the day after the war. But no one had and the dire consequences remain today, along with one million widows and orphans dependant on humanitarian aid. The anger vented by film and TV writer Armando Iannucci was palpable when he wrote about this earlier in the year. Without a thought for the future, the US sacked all of Iraq’s civil servants, everyone in the Ba’ath Party, and anyone in charge of the civil police. It was all done in such a rush that no one thought about disarming the military, leaving hundreds of thousands of angry Iraqi army veterans to roam around with their weapons. READ: Israel freed captives testify to being treated ‘extremely well’ by Hamas I’ve seen the work that Hamas does in Gaza. Its military wing came along after its social, political and welfare arms were established. You only have to be there for a few days to understand how the country works, and that it couldn’t work without Hamas. The leadership has as many PhDs in government as any Western cabinet, and is loved by the people because they live alongside them and share their difficulties,