CLARKSTON, Mich. – A Clarkston family is expressing gratitude for the many people who have rolled up their sleeves this summer to donate blood. Matt and Emily Buchanan’s 4 year-old son Jackson is fighting leukemia. He has needed multiple transfusions of blood and platelets throughout his treatment. The Buchanans want to raise awareness of how much each of those donations is needed and appreciated. “It’s not really on your radar. I mean, for most people, it’s like, ‘OK, we know that there’s blood drives, people benefit from it,’ but until you are directly affected, somehow you really see that tangible effect, and for Jack especially, it’s so literally a lifesaver,” said Matt Buchanan. “People have come up to us and said, ‘You know, I’ve always been too afraid’ or you know, ‘I just didn’t think that I’d be able to, but now that I know that your son benefits from that, I’m gonna go. I’m gonna go for my first time’ and those are the ones that are really cool to hear about the first-time donors,” said Emily Buchanan. Jackson has more treatment ahead, but he has made it through a particularly difficult phase. “He’s gone through it. He’s gone through the thick of it. And he’s come out the other side, just like he was when he started, but better,” said Matt Buchanan. As they work to support Jackson, the Buchanans are grateful for the people lifting them up. “Friends, family, the whole community has been above and beyond when it comes to support,” said Matt Buchanan. “Couldn’t have done it without them.” The family is also grateful to long-time blood drive sponsor Gardner-White. After seeing the rough condition of their old couch, the company gifted them a brand new one. “It’s amazing. We certainly appreciate it and with everything that we’ve gone through, you know, buying a couch wasn’t really in the cards for us for a little bit,” said Emily Buchanan. The Buchanans hope everyone who can will continue to donate blood, for Jackson and so many others who need it. “For something that will take maybe half hour, 45 minutes out of your day, it’s going to help somebody in dire need,” said Matt Buchanan. You can donate blood on Thursday, August 17 at Gardner White stores in Auburn Hills, Canton, Howell, Shelby Township, Warren, and Waterford. —> Gardner-White partners with American Red Cross to host blood drives in Metro Detroit: What to know You can also schedule a blood or platelet donation appointment by using the Red Cross Blood Donor app, visiting RedCrossBlood.org or calling 800-RED-CROSS (800-733-2767), sponsor code: gardnerwhite.
Day: July 2, 2024
Sign up to our Evening Headlines email for your daily guide to the latest news Sign up to our free US Evening Headlines email Three people have died in the New York City area after getting infections from a flesh-eating bacteria that can be caused by eating oysters or swimming in the ocean, according to health officials. One person died in Suffolk County on Long Island and two other victims were from Connecticut. A fourth victim fell ill but was later sent home from the hospital. The Centers for Disease Control says that the Vibrio vulnificus bacteria is deadly and kills one in five people who contract it. (Getty Images/iStockphoto) “While rare, the vibrio bacteria has unfortunately made it to this region and can be extraordinarily dangerous,” Governor Hochul said in a statement on Wednesday. “As we investigate further, it is critical that all New Yorkers stay vigilant and take responsible precautions to keep themselves and their loved ones safe, including protecting open wounds from seawater and for those with compromised immune systems, avoiding raw or undercooked shellfish which may carry the bacteria.” Vibrio vulnificus bacteria, which occurs naturally in saltwater coastal environments and can be found in higher concentrations from May to October when the weather is warmer, said the New York State Department of Health. “We are reminding providers to be on the lookout for cases of vibriosis, which is not often the first diagnosis that comes to mind,” Dr James McDonald, the New York state health commissioner said in the statement. “We are also suggesting to New Yorkers that if you have wounds, you should avoid swimming in warm seawater. And, if you have a compromised immune system, you should also avoid handling or eating raw seafood that could also carry the bacteria.” Health officials say that anyone with an open wound or recent tattoo or piercing should avoid warm seawater or cover the wound in a waterproof bandage. People with compromised immune systems are also told they should avoid eating raw or undercooked shellfish, such as oysters.
Colosseum, the new BBC series on the ancient amphitheatre, really should have an exclamation mark after it. It’s just so – exclamationy! A rollicking journey through 300 years of Roman history, via the construction of the enormous monument and the bloody games within, it could not be a more appealing introduction to the subject. Ideally, you will be new not just to the Romans, but also to Ridley Scott’s Gladiator aesthetic of the Roman empire that has dominated since Russell “Maximus Decimus Meridius, commander of the armies of the north, general of the Felix legions and loyal servant to the true emperor, Marcus Aurelius, father to a murdered son, husband to a murdered wife” Crowe stepped forward and asked if we were not entertained. Hopefully, too, you will not flinch at, but instead embrace with wide-eyed innocence, actors recreating pivotal tableaux when every penny has gone on CGI recreations of the architecture and not on the scripts. There are many enthusiastic talking heads – mostly from the US, which one suspects is the intended market for this prestigious primer. However, we are fielding Prof Bettany Hughes and Simon Sebag Montefiore on the home team. Stiffen the sinews and take your tablets and you can still enjoy the eight-episode round. We start in AD80 with – but of course! – the gladiators. The eight years of building work are complete and Rome’s new emperor, Titus, who has inherited the throne from his father, Vespasian (inaugurator of the Flavian dynasty), but still counts as an upstart and needs to secure his popular and political position as soon as possible, is about to open the venue for 100 days of sanguinary games. From mortal combat to executions of criminals in brutally innovative ways and animal hunts (venationes, coming to you in detail in episode three), the wobbly second rung of the Flavian dynasty was keen to see you got your lead token’s worth. And so is BBC Four, which follows the template laid down by the Starz network’s series Spartacus: Blood and Sand. If arterial spray is not your thing, please avert your eyes whenever someone starts swinging his gladius. Central to the grand opening of the Colosseum was the fight, recorded by the poet Martial, between the gladiators Verus and Priscus. According to the re-enactment casting, at least, Priscus was a lad who had been swept up in a raid and enslaved during a gap year in Germania. Titus had promised the heaving, volatile crowd an opening fight to the death, but Verus and Priscus were so well matched that each fought to exhaustion and surrendered, leaving the crowd agape and Titus in something of a cleft stick. I hope everyone who has seen the programme enjoys what an excellent, excellent joke I’ve just made. I will give you a moment to marvel at it. Thank you. The second episode concentrates on the building of the Colosseum – a subject that, perhaps more than any other, could have been, and hopefully will be, the focus of a series of its own. The scale of it, with only manual labour available, is mindboggling: 220,000 tonnes of dirt dug out for nine-metre-deep foundations; 99,000 cubic metres of travertine stone removed and transported from nine miles away; 300 tonnes of iron clamps; 1m bricks. All to the glory of Rome (the Flavians, more specifically). In AD81, the tyrannical Domitian became emperor after his brother died – of absolutely and completely natural causes, as emperors with tyrannical brothers waiting in the wings always did, so don’t look at me like that. He immediately ordered the master builder Haterius to build a hypogeum (a network of tunnels) and lifts beneath the amphitheatre to enable warriors, animals and scenery to emerge from the ground and blow the common people’s tiny minds. He gave him 18 months to do it. The year AD81 was the first and last time anyone felt sorry for a builder. Although the episodes feel remarkably effortless, they manage to impart the darnedest amount of information. The series comprises instalments about a female gladiator, a beast master, the martyred bishop Ignatius of Antioch, the gladiators’ doctor Galen (yes, that Galen) and the Colosseum’s final games, as the empire began to decline. By the time you reach the end of it, you will have learned a lot (if young) or remembered a surprising amount of what you had forgotten (if not) about the politics and sociology of the time, the advent of Christianity, the state of ancient medicine and the tentacular reach of Rome, plus its brutalities, its civilities and its influence over just about every field of human endeavour. Maximus Decimus Meridius, I was entertained. And more than a little educated, too.
COURIER STAFF LifeServe Blood Center needs both new and regular blood donors to roll up a sleeve this summer. The Cedar Falls Community Blood Drive is scheduled from 12:30 to 6 p.m. Aug. 28 at First United Methodist Church, 718 Clay St. Heart disease is the primary cause of death in men and women in the UK and the US. Yet the indicators of heart problems often go unnoticed, and prolonged waits for tests affect a significant portion of individuals. unbranded – Lifestyle Local lifesaving organizations like LifeServe Blood Center often see dips in blood donations due to blood donors’ busy summer schedules. From outdoor fun to weddings and vacations, people are busy. However, hospital patients are unable to reschedule their need for transfusions. So, this summer, the center is asking donors to spare just one hour and ensure blood is on the shelf when someone needs it. The entire whole blood donation process is typically one hour or less. And 60 minutes of one’s time could positively impact three families. Schedule a blood donation appointment online at lifeservebloodcenter.org or call 800-287-4903. People are also reading… LifeServe Blood Center is a non-profit, community based blood center that has served the needs of local hospitals and patients in our regions since 1947. As one of the 15 largest blood centers in the country, LifeServe provides blood products to 158 hospitals primarily in Iowa, Nebraska and South Dakota. LifeServe is committed to saving lives by providing premier service to volunteer blood donors and access to a safe, quality blood supply for hospitals and patients. Your donation with LifeServe will help save your neighbor, a friend or family member or a stranger on the street. YOU make a difference in YOUR community. Afghan women fight for survival after two years of Taliban rule, and more of today’s top videos Afghanistan’s Taliban has marked the second anniversary of their return to power, hope is fading for the hundreds still missing after the Maui wildfires, and more of today’s top videos. Afghanistan’s Taliban marked the second anniversary of their return to power, which means Afghan women have been fighting for survival for two… Relief workers in Lahaina continue the slow and meticulous work of searching for wildfire victims as Hawaii’s governor warns up to 20 bodies c… The recent wildfire which left Hawaii’s second largest island of Maui in ruin is now the 5th deadliest wildland fire in US history. The United States Army is facing a recruitment crisis. University of Chicago agreed to pay $13.5 Million as part of settling claims it engaged in a scheme to keep financial aid packages low. Veuer’… In what could be a landmark case, a Montana state court has ruled in favour of 16 youths who sued the state, claiming its use of fossil fuels … A new COVI-19 vaccine is set to be released next month amidst rising cases of the “Eris” variant, a form of the Omicron variant. 0 Comments #lee-rev-content { margin:0 -5px; } #lee-rev-content h3 { font-family: inherit!important; font-weight: 700!important; border-left: 8px solid var(–lee-blox-link-color); text-indent: 7px; font-size: 24px!important; line-height: 24px; } #lee-rev-content .rc-provider { font-family: inherit!important; } #lee-rev-content h4 { line-height: 24px!important; font-family: “serif-ds”,Times,”Times New Roman”,serif!important; margin-top: 10px!important; } @media (max-width: 991px) { #lee-rev-content h3 { font-size: 18px!important; line-height: 18px; } } #pu-email-form-daily-email-article { clear: both; background-color: #fff; color: #222; background-position: bottom; background-repeat: no-repeat; padding: 15px 0 20px; margin-bottom: 40px; border-top: 4px solid rgba(0,0,0,.8); border-bottom: 1px solid rgba(0,0,0,.2); display: none; } #pu-email-form-daily-email-article, #pu-email-form-daily-email-article p { font-family: -apple-system, BlinkMacSystemFont, “Segoe UI”, Helvetica, Arial, sans-serif, “Apple Color Emoji”, “Segoe UI Emoji”, “Segoe UI Symbol”; } #pu-email-form-daily-email-article h2 { font-size: 24px; margin: 15px 0 5px 0; font-family: “serif-ds”, Times, “Times New Roman”, serif; } #pu-email-form-daily-email-article .lead { margin-bottom: 5px; } #pu-email-form-daily-email-article .email-desc { font-size: 16px; line-height: 20px; margin-bottom: 5px; opacity: 0.7; } #pu-email-form-daily-email-article form { padding: 10px 30px 5px 30px; } #pu-email-form-daily-email-article .disclaimer { opacity: 0.5; margin-bottom: 0; line-height: 100%; } #pu-email-form-daily-email-article .disclaimer a { color: #222; text-decoration: underline; } #pu-email-form-daily-email-article .email-hammer { border-bottom: 3px solid #222; opacity: .5; display: inline-block; padding: 0 10px 5px 10px; margin-bottom: -5px; font-size: 16px; } @media (max-width: 991px) { #pu-email-form-daily-email-article form { padding: 10px 0 5px 0; } } .grecaptcha-badge { visibility: hidden; } Get local news delivered to your inbox! 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EAST MORICHES, NY — It’s a story of love, pure and simple. A blood drive that Arlexa Karoutsos has organized for Thursday in Center Moriches in memory of her mother Diane Mazarakis, who died in January, is not just about the heartbreaking loss she endured. Instead, it’s about living as her mother would have, a life full of laughter, of joy, of beach days and travel — and of donating blood, so that others can continue to make treasured memories. Mazarakis herself organized a blood drive every year in honor of her own mother Arlette and now, Karoutsos is doing the same thing, to honor the woman who taught her how to live fully and embrace every moment. The New York Blood Center, or NYBC, will be hosting the blood drive on Thursday, August 17 from 2 p.m. to 8 p.m. at the East Moriches Fire Department, located at 9 Pine Street. Find out what’s happening in Center Moriches-Eastportwith free, real-time updates from Patch. Mazarakis organized blood drives in honor of her mother from 2018 to 2020, until the onset of the pandemic. Mazarakis was ultimately diagnosed with acute myeloid leukemia, and fought a battle that spanned two years and required numerous blood transfusions. She became a recipient of the blood donations she had tirelessly advocated for throughout the years prior, NYBC said. Find out what’s happening in Center Moriches-Eastportwith free, real-time updates from Patch. Diane passed away on January 6. She was just 65 years old. Karoutsos, NYBC said, “recognized the importance of continuing her mother’s legacy and the profound impact that blood donors had in extending her mother’s life, allowing for her to have two additional years with her family. Diane’s daughter asks that the community honor her mother’s memory by donating blood and saving a life.” Blood donors can give every 56 days, and platelet donors can give twice per month, NYBC said. The U.S. Food and Drug Administration recently lifted eligibility restrictions for individuals who lived in Europe during certain periods of time, NYBC added. To view current eligibility guidelines, click here or call 800-688-0900. NYBC added that it only takes one hour to donate, and a single donation can save multiple lives. Roughly 1 in 7 hospital admissions require a blood transfusion. Those in need include cancer patients, accident, burn, or trauma victims, newborn babies and their mothers, transplant recipients, surgery patients, chronically transfused patients suffering from sickle cell disease or thalassemia, and many more, NYBC said. Speaking with Patch, Karoutsos described the mother she loved beyond measure: “My mom was the most positive, upbeat, fun-spirited person I know. She spent her summers on the beaches in New York and winters on the beaches of Florida,” she said. Her mother, she said, organized blood drives in honor of her mother to continue her legacy and continue helping people. And then came unthinkable news: “My mom was diagnosed with acute myeloid leukemia in January, 2021 after yearly blood work before going to Florida for the winter. She had the worst kind of leukemia —with the worst genetic mutations.” Despite the grim diagnosis, her mother never lost her sparkle. “Throughout treatment, my mom maintained such a positive outlook,” Karoutsos said. “We always had so many laughs on the way to appointments.” Her mother received the majority of her treatment at Memorial Sloan Kettering. After intensive chemo, her mother received a bone marrow transplant, Karoutsos said; her aunt was a 100 percent match and donated stem cells to her mother. “A few months later, the leukemia was back,” she said. Her mother fought tirelessly, with additional treatments in Manhattan, a clinical trial at the MD Anderson Cancer Center in Houston, and even a visit to the Moffitt Cancer Center in Tampa, Karoutsos said. “My mom was determined this leukemia would not win,” she said. And until the day she died, she never stopped living. “We continued to travel on vacations, even against the doctors’ wishes. She lived every day to the fullest. She hoped to change the path for the patients behind her. We would always push the boundaries during treatment — if it was sneaking to Puerto Rico for the weekend or to a Jimmy Buffett concert. . . We didn’t let the leukemia win.” Courtesy Arlexa Karoutsos Throughout the months that her mother fought the leukemia, blood donations were critical, Karoutsos said. “Due to the leukemia taking over, my mom had very, very low white blood cells, platelets, and red blood cells. Toward the end of treatment, she was receiving blood twice a week. Without the generous donations, my mom wouldn’t have had an extra two years of living.” Still, the pain of losing her mother is palpable. “The hardest part of her leukemia journey was watching her be a patient. I wished and prayed more than anything to make her better, so we could continue living,” Karoutsos said. The heartache of memories never made echoes. “I found out in early September that my husband and I were expecting our first child. My mom passed away when I was 4 months pregnant,” Karoutsos said. “We are so grateful that she was there for our gender reveal, and to hear the baby’s heartbeat for the first time. Our baby girl is named Charlette Diana. Named after my grandmother Arlette and mom Diane.” Despite the sadness, Karoutsos finds a way to face the future with positivity and grace, led by her mother’s example. “We find the strength to go forward every day because that’s exactly what my mom would want. She would want me to put on a smile and be the best version of myself every day,” she said. She added: “If you ask anyone, they will tell you how full of life my mom was. She was always on the go with somewhere fun to be. If it was live music at the beach or a sailing trip in the Bahamas. She always had something going on.” Karoutsos organized the blood drive for this week;
The FDA has granted a breakthrough device designation to HLA-LOH as a companion diagnostic test, according to an announcement from Tempus.1 The test features a machine-learning model designed to analyze data from the next-generation sequencing (NGS)–based xT CDx assay, which is a 648-gene NGS assay for solid tumor profiling and a companion diagnostic for patients with colorectal cancer that received FDA approval in May 2023.2 The assay is designed to identify patients with solid tumors who may benefit from specific targeted therapies if their tumors underwent allele-specific loss of heterozygosity (LOH) for specific HLA class I alleles.1 “HLA-LOH provides a clear molecular distinction between cancer and non-cancer cells and is a potential biomarker for immune therapy resistance. The Tempus HLA-LOH test is intended to measure this biomarker and better understand which patients may respond to new therapies. This breakthrough device designation from the FDA recognizes the novelty and potential clinical impact of our HLA-LOH test for this promising biomarker,” Kate Sasser, PhD, chief scientific officer of Tempus, stated in a news release. “HLA-LOH is of special interest for the application of cell therapy to treat solid tumors, but also has broader potential for other precision medicine approaches in oncology, including in combination with other established biomarkers,” Sasser added. “The Tempus test is being developed to identify HLA-LOH and may help optimize existing therapies and facilitate the advancement and implementation of novel and transformative treatments.” xT CDx is a qualitative NGS-based in vitro diagnostic device designed to identify substitutions such as single nucleotide and multinucleotide variants, as well as insertion and deletion alterations in 648 genes. Additionally, it is capable of detecting microsatellite instability status through DNA isolated from formalin-fixed paraffin embedded tumor tissue specimens and DNA isolated from matched normal blood or saliva from patients with previously diagnosed solid malignant neoplasms.2 For patients with CRC, xT CDx can be utilized as a companion diagnostic to identify those with KRAS wild-type disease (absence of mutations in codons 12 or 13) who could benefit from treatment with cetuximab (Erbitux), or those who could be eligible for treatment with panitumumab (Vectibix) through the detection of KRAS wild-type (absence of mutations in exons 2, 3, and 4) and NRAS wild-type (absence of mutations in exons 2, 3, or 4) disease.3 The detection of alterations by xT CDx was compared with data from an externally validated orthogonal method (OM), with 114 overlapping genes between the 2 assays. Samples of 416 patients across 31 different tumor types were used to compare the detections of mutations, insertions, and deletions between the 2 methods. The samples were derived from patients with CRC (n = 69), breast cancer (n = 44), ovarian cancer (n = 38), glioblastoma (n = 34), non–small cell lung cancer (n = 29), endometrial cancer (n = 26), clear cell renal cell carcinoma (n = 22), bladder cancer (n = 18), melanoma (n = 17), pancreatic cancer (n = 14), thyroid cancer (n = 12), low-grade glioma (n = 12), sarcoma (n = 10), tumor of unknown origin (n = 8), meningioma (n = 7), prostate cancer (n = 7), gastrointestinal stromal tumor (n = 7), endocrine tumor (n = 6), gastric cancer (n = 5), head and neck squamous cell carcinoma (n = 4), kidney cancer (n = 3), brain cancer (n = 3), small cell lung cancer (n = 3), biliary cancer (n = 3), cervical cancer (n = 3), esophageal cancer (n = 3), oropharyngeal cancer (n = 2), liver cancer (n = 2), head and neck cancer (n = 2), mesothelioma (n = 2), and adrenal cancer (n = 1). Concordance in hotspot and non-hotspot regions were identified, and positive and negative percent agreements (PPA, NPA) for each type of variant between the 2 assays were used to assess the accuracy of xT CDx. Findings showed that 148 variants reported as somatic through the OM were detected as germline by xT CDx. A hotspot concordance analysis with the OM examined variants reported in hotspot regions that overlapped with OM targeted regions. Of the 416 samples, 164 featured at least 1 reported variant in an overlapping hotspot region, and 214 base pairs intersected at the defined hotspot regions of both the xT CDx and OM targeted regions. Investigators assessed 192 reported variants in hotspots from both assays, including 187 substitutions across 10 genes and 5 INDELs spanning 4 genes. They calculated the PPA and NPA for substitutions and INDELS in hotspot regions through the total variant counts of each classification across tumor samples to assess the accuracy of xT CDx. Among the 69 CRC samples tested with the OM, the detection of specific KRAS and NRAS CDx variants was examined. Among 31 CDx variants identified through OM, 31 were also detected by xT CDx, resulting in a PPA of 100% (95% CI, 88.8%-100.0%). Additionally, 649 variants were negative by the OM, and 648 were negative by xT CDx, leading to a NPA of 99.8% (95% CI, 99.1%-100.0%). References FDA grants breakthrough device designation to Tempus’ HLA-LOH companion diagnostic test. News release. Tempus. August 15, 2023. Accessed August 16, 2023. https://www.tempus.com/news/fda-grants-breakthrough-device-designation-to-tempus-hla-loh-companion-diagnostic-test/ Tempus receives US FDA approval of xT CDx, a NGS-based in vitro diagnostic device. News release. Tempus. May 1, 2023. Accessed August 16, 2023. https://www.tempus.com/news/tempus-receives-u-s-fda-approval-for-xt-cdx-a-ngs-based-in-vitro-diagnostic-device/ xT CDx: Technical information. Tempus Labs, Inc. February 2023. Accessed August 16, 2023. https://www.tempus.com/wp-content/uploads/2023/05/Tempus-xT-CDx_Technical-Information.pdf
The cause of death of Whanganui pensioner Carmen Walker after an isolated limb infusion at Waikato Hospital in 2010 is the subject of a coronial inquest. Photo / Stuart Munro Two buckets that contained the volume of blood drained out of Carmen Walker in a hospital procedure that ended her life were disposed of the day she died. It prevented any chance of measuring the amount of blood in the buckets and pinpointing the exact cause of Walker’s death, which is now – 13 years later – being probed by a coroner. According to a nurse involved in Walker’s August 2010 isolated limb infusion at Waikato Hospital, it was hospital policy that waste from a procedure or surgery was only kept if the patient died in theatre. In Walker’s case, the 78-year-old great-grandmother from Whanganui was barely alive when she left the procedure room and was not expected to survive the night after the melanoma treatment that was supposed to extend her life went wrong. Advertisement Advertise with NZME. The nurse, who has interim name suppression, told an inquest into Walker’s death she had never experienced such a serious incident in theatre and she was unsure what to do following the patient’s transfer to the intensive care unit. Walker suffered a cardiac arrest after the deflation of tourniquets isolating her leg to allow infusion of the concentrated chemotherapy drug melphalan to treat the cancer that had spread from her right ankle. Resuscitation ensued to stabilise Walker but by then her brain had been deprived of oxygen for too long after the left ventricle of her heart was found empty, meaning there was no blood for the heart to pump. The nurse said she and others cleaned up the room so Walker’s husband Bob and son Craig could sit with her after they were delivered the unexpected and devastating news she was not likely to survive. Advertisement Advertise with NZME. There were two buckets – or containers – in use in the Harris Suite of the Radiology Department that afternoon, the nurse told the inquest before Coroner Alexander Ho at the Hamilton District Court yesterday. A white container placed inside a purple bucket collected the saline after it “washed out” the leg, as well as Walker’s tainted blood which was exsanguinated before the tourniquets were released. This bucket was at the foot of the bed next to the nurse. The second container collected the perfusionist’s equipment waste as well as the melphalan mixed with blood. After Walker suffered a cardiac arrest and was resuscitated the two buckets were moved to another room as part of the clean-up. The nurse said the lead surgeon, who also has interim name suppression, and observing surgeon Dr Adam Greenbaum, entered the annex room and went to the perfusionist’s bucket to see how much blood was in it because it was not measured. However, the nurse had to warn the surgeon not to put his hands in the bucket because it contained cytotoxic waste. She said the pair left before she had a chance to tell them the other bucket had been sealed ready for disposal and was sitting on a nearby shelf. It was suggested the combined volume of blood in both buckets could have been as much as five litres – the amount circulating in the body – but there was no way to be sure because of the other waste also in the buckets. Coroner Alexander Ho is presiding over the inquest into the death of Carmen Elizabeth Walker at Waikato Hospital in 2010. Photo / Mike Scott The nurse later called the hospital’s theatre coordinator for direction about whether to keep the waste because of Walker’s bleak prognosis but was told the buckets could be disposed of as usual because the policy dictated that waste only be kept when a patient died in theatre. She said the same policy was still in place today. Advertisement Advertise with NZME. One theory on the cause of Walker’s massive blood loss suggested by the surgeon in the first coronial inquiry in 2011, was that the tourniquets were not sufficiently compressing the arterial blood supply to the limb, allowing blood to leak into the limb as the venous system was washed out. The nurse said she checked the two tourniquets during the procedure and they were not leaking. On Tuesday the inquest heard the perfusionist, who was in charge of the limb and the fluid going in and out, and the anaesthetist both believed Greenbaum exsanguinated Walker – a necessary part of the procedure to drain all the blood from her leg tainted with melphalan. But the nurse said it was definitely the lead surgeon who did this. She also confirmed a crash call was made by the Harris Suite staff though the anaesthetist later testified this was likely a mistake because only an emergency anaesthetist was needed. The nurse also described how she was so concerned there was no debrief of the event she rang a colleague the next day and dictated a detailed note describing what happened. However, the nurse said she did not fill out a serious incident report of the procedure despite it being hospital policy. Advertisement Advertise with NZME. This was in part because she injured her back during the procedure and took several days off work to recover. The injury was also the reason she rang her colleague and dictated the note because she didn’t know if she would be able to be involved in any debrief. The nurse finished by expressing her sympathy to the Walker family for their loss. The inquest also heard from intensive care nurse Analea Cruz who said she had no memory of Walker but referred to her notes that Walker oozed blood from where the catheters had earlier been inserted. Her notes also described Walker as having melena, a black stool indicative of upper gastrointestinal tract bleeding, pointing to Walker having internal bleeding. When it was put to Cruz that evidence from two
Scott Kopetz, MD, PhD, FACP, professor, Department of Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, discusses the phase 3 BREAKWATER trial (NCT04607421) in patients with BRAF V600E–mutant metastatic colorectal cancer (mCRC). The phase 3 trial evaluated encorafenib (Braftovi) plus cetuximab (Erbitux) with or without mFOLFOX6 or FOLFIRI vs chemotherapy alone in this patient population. Kopetz shares that the trial investigators are encouraged by the response rates that were reported, adding that biomarker findings were integrated into the data as well. One emerging biomarker is circulating tumor DNA (ctDNA), Kopetz says. In patients with BRAF V600E mutations, investigators can measure BRAF V600E–mutated ctDNA and track how it changes with treatment, he explains. Most patients in the phase 3 trial who received chemotherapy combined with encorafenib and cetuximab had complete clearance of their BRAF V600E–mutant ctDNA, Kopetz emphasizes. Although this is an encouraging sign of efficacy, it does not mean that these tumors are completely eradicated, but rather that the amount of disease has been driven below the limits of detection. Overall, the BREAKWATER investigators are excited by both the safety and efficacy data, Kopetz continues, adding that the BRAF V600E–mutant mCRC population needs new and innovative treatment strategies. Further research and new therapeutic approaches, such as bringing targeted therapies into earlier lines of therapy, may improve outcomes for these patients, Kopetz explains. Moreover, by combining these new approaches with cytotoxic chemotherapy, investigators may harness some of the biological synergy between these combinations, Kopetz adds. Overall, these new approaches are anticipated to improve responses, progression-free survival, and ultimately, overall survival for this population, he concludes.
August 16, 2023 — A new American Heart Association (AHA) scientific statement highlights evidence that supports shared decision-making, a term that describes the process of ensuring patients have the knowledge and tools to make decisions about their health in collaboration with their professional health care team. The statement was published August 14 in the American Heart Association’s flagship, peer-reviewed journal Circulation. More than 100 trials have demonstrated that shared decision-making improves patient’s understanding, acceptance and satisfaction with their health care, yet adequate levels of shared decision-making occur in as few as 10% of face-to-face consultations across a variety of health care specialties. The statement details the key components of shared decision-making: – clearly communicated, unbiased evidence about risks, benefits and reasonable alternatives to treatment; – clinical expertise provided in a way that is relevant to the patient; and – inclusion of the patient’s values, goals and preferences in the decision process. The statement presents models of shared decision-making and ways to measure it in research, in addition to strategies to promote its use. Potential solutions to increase shared decision-making in cardiovascular care include reimbursement for consultations, team-based care, integrating decision aids in electronic records, and training clinicians on communication skills that support shared decision-making more effectively and are sensitive to the cultural, racial, ethnic and language considerations for each patient. The abstract offers the following: “Shared decision-making is increasingly embraced in health care and recommended in cardiovascular guidelines. Patient involvement in health care decisions, patient-clinician communication, and models of patient-centered care are critical to improve health outcomes and to promote equity, but formal models and evaluation in cardiovascular care are nascent. Shared decision-making promotes equity by involving clinicians and patients, sharing the best available evidence, and recognizing the needs, values, and experiences of individuals and their families when faced with the task of making decisions. Broad endorsement of shared decision-making as a critical component of high-quality, value-based care has raised our awareness, although uptake in clinical practice remains suboptimal for a range of patient, clinician, and system issues.” “Strategies effective in promoting shared decision-making include educating clinicians on communication techniques, engaging multidisciplinary medical teams, incorporating trained decision coaches, and using tools (ie, patient decision aids) at appropriate literacy and numeracy levels to support patients in their cardiovascular decisions,” noted the authors, writing that the scientific statement “shines a light on the limited but growing body of evidence of the impact of shared decision-making on cardiovascular outcomes and the potential of shared decision-making as a driver of health equity so that everyone has just opportunities.” It further added: “Multilevel solutions must align to address challenges in policies and reimbursement, system-level leadership and infrastructure, clinician training, access to decision aids, and patient engagement to fully support patients and clinicians to engage in the shared decision-making process and to drive equity and improvement in cardiovascular outcomes.” This statement was prepared by the writing group committee on behalf of ten American Heart Association Councils and, according to the American Heart Association statement, include: Dennison Himmelfarb CR, Beckie TM, Allen LA, Commodore-Mensah Y, Davidson PM, Lin G, Lutz B, Spatz ES; on behalf of the American Heart Association Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Quality of Care and Outcomes Research; Council on Hypertension; Council on the Kidney in Cardiovascular Disease; Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Council on Lifestyle and Cardiometabolic Health; Council on Peripheral Vascular Disease; Council on Epidemiology and Prevention; and Stroke Council. American Heart Association scientific statements promote greater awareness about cardiovascular diseases and help facilitate informed health care decisions. Scientific statements outline what is currently known about a topic and what areas need additional research. While scientific statements inform the development of guidelines, they do not make treatment recommendations. This new statement was approved by the American Heart Association Science Advisory and Coordinating Committee on May 1, 2023, and the American Heart Association Executive Committee on May 17, 2023. More information: www.heart.org Reference: Shared decision-making and cardiovascular health: a scientific statement from the American Heart Association. Circulation. 2023;148:e•••–e•••. doi: 10.1161/CIR.0000000000001162
The bacteria is found in raw seafood, like oysters, and warm, brackish waters. Climate change may increase the risk of infections from the deadly bacteria farther north. Three people in the New York City area have died in recent weeks and a fourth person was hospitalized after contracting infections from a flesh-eating bacteria that can be caused by eating raw oysters or swimming in saltwater, health officials in New York and Connecticut said. Infections from the bacteria, called Vibrio vulnificus, are rare but extremely dangerous. The Centers for Disease Control and Prevention estimates that one in five people who become infected die. Many survivors lose limbs to amputations, according to the C.D.C. “We are reminding providers to be on the lookout for cases of vibriosis, which is not often the first diagnosis that comes to mind,” Dr. James McDonald, the New York state health commissioner said in a statement on Wednesday. People with open wounds should avoid swimming in warm seawater, he said. And people with compromised immune systems should be careful with eating or handling raw seafood. One of the New York area deaths was in Suffolk County, on Long Island; two others were in Connecticut. In the fourth case, also in Connecticut, a person was sickened but later released from the hospital. Vibriosis is caused by several species of bacteria, including the Vibrio vulnificus bacteria, which can be found in salt water, especially when the weather is warm, New York health officials said. Symptoms include diarrhea, stomach cramps, vomiting, fever and chills. Exposure can also result in ear infections and cause sepsis and life-threatening wound infections. The flesh around an open wound can die, which is why Vibrio vulnificus is called a “flesh-eating” bacteria. “It gets very nasty,” said Dr. William Schaffner, an infectious disease specialist at the Vanderbilt University School of Medicine. The infection can destroy the soft tissues, he said, before getting into the bloodstream and causing sepsis. Healthy people should not be too concerned, he said. But people with liver problems, he said, should be cautious with seafood: “Eat the shrimp, rather than the oyster.” In the Connecticut cases, two people had open cuts and were exposed to water in the Long Island Sound, according to Christopher Boyle, a spokesman for the state’s health department. A third Connecticut resident became sick after eating raw oysters, though not at a restaurant in the state, and not harvested from the Sound, said Rebecca E. Murphy, a spokeswoman for the state agriculture department. “Nobody has ever been infected with Vibrio from eating shellfish or oysters in the state of Connecticut,” Dr. Manisha Juthani, the state’s public health commissioner, said at a news conference earlier this week. New York officials are still investigating whether the death in Suffolk County was caused by bacteria that was encountered in local waters or elsewhere. The bacteria are more common in the summer months. As ocean temperatures rise, more people may be at higher risk of infection, according to a study published this spring in the journal Scientific Reports. Once, the bacteria were rare north of Georgia, but they have been found farther north in recent years. From 1988 to 2018, wound infections from the virus increased from 10 cases per year to 80 cases a year on the East Coast, the researchers found. “This is showing the interconnectedness of our health and ocean health,” said Elizabeth Archer, the lead author. There have been other national spikes related to coastal surges, as infection-bearing water is pushed further inland. Last fall, after Hurricane Ian struck Florida, the state’s health department recorded what it described as an “abnormal increase” in cases. After Hurricane Katrina, in 2005, at least five people died of illnesses caused by Vibrio bacteria. Connecticut has seen a few cases in recent years. One person died of a Vibrio vulnificus infection in the state in 2019. In 2020, five cases were reported; all recovered. The people who became infected had open wounds and were exposed to salt or brackish water. Partly in response to the 2020 outbreak, the state now tests oysters for Vibrio vulnificus, said Emily Marquis, an environmental analyst with the bureau of aquaculture and laboratory services. Inspectors have never detected it in the state’s commercial oysters, said David Carey, the director of the bureau. Connecticut, which has a thriving oyster industry, also implemented rules about the storage and freezing of oysters after a 2013 outbreak of a similar bacterial strain, Vibrio parahaemolyticus, sickened 23 people there. Connecticut’s protocols are designed to keep oysters cold, below or equal to 50 degrees Fahrenheit. Oysters must be refrigerated or placed in an ice slurry, depending on where they are harvested. The agriculture department said that there have been no Vibrio outbreaks since the protocols were put in place in 2014. “Maintaining cool temperatures is inhibiting bacteria growth,” said Tessa L. Getchis, who trains farmers in seafood cultivation practices with the Connecticut Sea Grant and UConn Extension Program. “Which is what you want. That’s why we refrigerate anything.” News of the deaths have worried some Connecticut residents. But the organizers of the annual Milford Oyster Festival, set for Saturday, say they are confident about safety. “There’s no reason for us to be alarmed over this,” said Trisha Kozloski, who organizes all the oyster sales for the festival. Organizers plan to provide 30,000 oysters, all harvested off the town’s coast. All are put on ice or refrigerated immediately, and festival workers regularly check the temperature of the truck, and of individual oysters, she said. “But we’re shucking to order, so the oysters aren’t sitting around,” she said, adding: “Nothing has changed. There’s no greater risk this year than there ever has been before. And the risk is very, very low.”