Day: July 1, 2024

Jul 01

Japanese drugmaker urges G7 to fix infectious diseases market

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Jul 01

Colon Cancer Accelerated by Age-Related Changes in Blood System

Researchers at the University of Florida College of Medicine have uncovered how common age-related changes in the blood system can exacerbate certain colon cancers. Their findings also suggest how these effects may be therapeutically targeted to reduce tumor growth and improve patient survival. Their new study is published in the Journal of Experimental Medicine in an article titled, “Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer.” As we age, the hematopoietic stem cells that reside in the bone marrow and give rise to all of the body’s different blood cells gradually acquire mutations in their DNA. Most of these mutations have no effect, but some can enhance a particular stem cell’s ability to survive and proliferate, resulting in large numbers of blood cells that carry the same mutation, which is known as clonal hematopoiesis. Clonal hematopoiesis is even more frequently seen in patients with many other types of cancer outside of the blood system and is associated with faster tumor progression and shorter survival times. “However, whether the presence of clonal hematopoiesis causes the aggressive phenotype of unrelated solid tumors has not been vigorously addressed,” said Olga A. Guryanova, MD, PhD, now an associate professor at the University of Florida College of Medicine and a member of the University of Florida Health Cancer Center, who led the new JEM study. “Clonal hematopoiesis (CH) is defined as clonal expansion of mutant hematopoietic stem cells absent diagnosis of a hematologic malignancy,” wrote the researchers. “Presence of CH in solid tumor patients, including colon cancer, correlates with shorter survival. We hypothesized that bone marrow–derived cells with heterozygous loss-of-function mutations of DNMT3A, the most common genetic alteration in CH, contribute to the pathogenesis of colon cancer. In a mouse model that combines colitis-associated colon cancer (CAC) with experimental CH driven by Dnmt3a+/Δ, we found higher tumor penetrance and increased tumor burden compared with controls.” Compared with normal mice (top), colonoscopies detect more, and larger, tumors in the intestines of mice with clonal hematopoiesis (bottom). [© 2023 Feng et al. Originally published in Journal of Experimental Medicine. https://doi.org/10.1084/jem.20230011] Guryanova and colleagues decided to investigate the role of clonal hematopoiesis in colitis-associated colon cancer (CAC). Inflammatory bowel disease, including ulcerative colitis and Crohn’s disease, is a well-known risk factor for colon cancer, and clonal hematopoiesis is prevalent in both IBD and colon cancer patients. The team generated mice with clonal hematopoiesis by transplanting them with blood stem cells lacking one copy of Dnmt3a, the most frequently mutated gene in clonal hematopoiesis patients. The team observed that CAC occurred more frequently, and developed more rapidly, in mice with clonal hematopoiesis, resulting in larger tumors with a worse histopathology. The researchers determined that one way clonal hematopoiesis promotes the development of CAC is by increasing the number of blood vessels that supply the intestinal tumors with the nutrients and oxygen they need to grow. Blocking the formation of these extra blood vessels with axitinib, a drug approved by the FDA to treat advanced kidney cancer, inhibited the growth of CAC tumors in mice with clonal hematopoiesis. “Our results show that alterations in Dnmt3a in bone marrow stem cells can have profound impact on the development of CAC through multiple mechanisms, some of which may be therapeutically targetable,” Guryanova said. “Our findings, for the first time, solidify the causal relationship between clonal hematopoiesis and the severity of solid tumors and identify potential therapeutic strategies.”

Jul 01

Opioid Use Disorder Overview

Opioid use can begin with prescription painkillers. When the use of these powerful substances becomes an addiction, life can spiral out of control, threatening a person’s physical, mental, and social well-being. Family and friends are often the first to recognize the wide-ranging signs of opioid abuse. Opioid Use Disorder (OUD) refers to a pervasive and complex medical condition wherein an individual’s life becomes ensnared in the grasp of opioid medications, entailing a relentless cycle of acquisition, consumption, recuperation from their effects, and the subsequent reinitiation of this distressing loop. Characterized by its enduring nature, OUD orchestrates a distressing dance of alternating phases encompassing moments of recuperative respite intertwined with disheartening relapses. This intricate malady is discerned and diagnosed by healthcare professionals through a constellation of varied symptoms, forming a diagnostic framework to comprehend its multifaceted manifestation. Medical practitioners approach the treatment of Opioid Use Disorder with a multifaceted approach, harnessing the synergistic potential of both pharmacological agents and tailored behavioral interventions. This multifarious strategy endeavors to address the multifaceted nature of OUD, targeting not only the physiological aspects of opioid dependence but also the intricate interplay of psychological and social factors that contribute to its perpetuation. Regrettably, the United States finds itself in the throes of an unprecedented opioid crisis, an epidemic that transcends mere statistics and casts a daunting shadow over public health. This burgeoning predicament prompted the declaration of a Public Health Emergency in 2017, highlighting the severity of the situation. An alarming testament to the dire consequences of this crisis, nearly 50,000 lives were tragically lost to opioid overdoses in that same year, casting an indelible mark of sorrow on countless families and communities across the nation. In the face of this pervasive challenge, concerted efforts are imperative to construct a comprehensive and compassionate response. Beyond the realm of medical intervention, initiatives encompassing education, prevention, harm reduction, and destigmatization play a pivotal role in stemming the tide of Opioid Use Disorder. It is through the collective mobilization of healthcare practitioners, policymakers, communities, and individuals that a multi-pronged strategy can be realized, offering a glimmer of hope amidst the grim landscape of this modern-day epidemic. What Is It? Opioids, potent analgesic agents, represent a category of pharmaceutical compounds frequently prescribed by medical professionals in the aftermath of injuries, surgical interventions, dental procedures, or in cases where individuals are grappling with the challenging specter of cancer. This class encompasses a range of substances, including but not limited to heroin, morphine, fentanyl, and oxycodone, each possessing its own distinct potency and mechanism of action. Although initially administered with the intention of providing relief from debilitating pain, the insidious nature of opioids can lead to a profound and disconcerting phenomenon known as opioid use disorder (OUD), a condition wherein the initial therapeutic use devolves into a tumultuous cycle of unchecked consumption. Opioid use disorder unfurls as a relentless spiral, an intricate web ensnaring individuals within its grasp. The journey toward OUD often begins with a legitimate medical necessity, a response to the exigencies of post-operative agony or the wrenching discomfort associated with cancer. However, the treacherous trajectory of OUD becomes apparent when the use of these substances transcends the boundaries of necessity and evolves into a self-perpetuating pattern of excessive consumption. This gradual shift is characterized by a compelling need for escalating doses to replicate the initial pleasurable or euphoric sensations experienced, leading to a cascading array of negative consequences that reverberate across various facets of one’s life. The ramifications of opioid misuse extend far beyond the realm of physical health, infiltrating the intricate tapestry of relationships, finances, and societal engagement. As individuals grapple with the clutches of OUD, interpersonal dynamics suffer the toll of strained connections and eroding trust. Financial stability succumbs to the weight of relentless expenditure on escalating drug doses, often culminating in dire money problems that perpetuate a cycle of desperation. Moreover, the erratic trajectory of opioid use disorder can precipitate a descent into criminal behavior as individuals strive to secure the means to feed their insatiable cravings. In the wake of this multifaceted predicament, the imperative to address opioid use disorder extends beyond the realm of individual health and navigates the corridors of public health and societal well-being. Healthcare practitioners, policymakers, and communities alike stand at a pivotal juncture to devise comprehensive strategies that embrace prevention, intervention, and compassionate support. By fostering education, implementing harm reduction initiatives, and promoting destigmatization, society can collectively construct a safety net to prevent the further proliferation of this disheartening epidemic. The complex tale of opioids and their perilous consequences necessitates a nuanced and sustained response, underpinned by empathy, understanding, and a commitment to eradicating the pervasive shadows cast by opioid use disorder. Through the amalgamation of medical expertise, policy reform, and community engagement, a brighter, opioid-resilient future can be envisaged—one in which individuals find solace, healing, and restoration amidst the darkness that opioid misuse seeks to perpetuate. Types Distinguishing between drug tolerance, drug dependence, and drug use disorder (commonly referred to as addiction) is essential for a comprehensive understanding of the complex dynamics that can unfold with substance use. It’s crucial to recognize that these terms denote distinct stages and manifestations of the relationship between an individual and a drug. Firstly, drug tolerance and drug dependence represent physiological responses to continued drug exposure. Drug tolerance occurs when the body adapts to a drug’s presence, leading to reduced responsiveness to its effects over time. On the other hand, drug dependence involves the body becoming accustomed to the presence of a drug to function normally, often resulting in withdrawal symptoms upon cessation of use. It’s noteworthy that these physiological adaptations can occur without necessarily being accompanied by the compulsive mental preoccupation associated with addiction. Substance use disorder, or addiction, marks a much more intricate and all-encompassing phenomenon. It is characterized by a profound psychological and behavioral attachment to a drug, to the point where it dominates nearly every facet of an individual’s life. The relationship with the substance becomes paramount, overshadowing

Jul 01

What Doctors Want You to Know About Situational Depression

Depression is a prevalent mental health condition that can manifest in various forms, and among these is situational depression. Unlike general depression, situational depression is distinctly tied to specific circumstances or events in an individual’s life that trigger feelings of intense sadness and emotional turmoil. These events can include situations such as the loss of a job, the passing of a loved one, a severe illness diagnosis, or other major life upheavals. Understanding situational depression entails delving into its defining characteristics, its symptoms, therapeutic approaches for addressing it, and the typical duration of its effects. Situational depression is often described as a response to external stressors rather than being rooted in a person’s inherent mental state. It arises from the emotional strain caused by significant life events, disrupting an individual’s emotional equilibrium and causing a notable decline in their overall well-being. Unlike chronic or clinical depression, which may have genetic, biochemical, and psychological factors contributing to its development, situational depression can be more clearly linked to specific triggers. The symptoms of situational depression closely mirror those of general depression, although they are distinctly tied to the triggering event. People experiencing situational depression might feel overwhelming sadness, hopelessness, and a profound sense of loss. They may experience changes in sleep patterns, appetite, and energy levels. Moreover, irritability, difficulty concentrating, and a lack of interest in activities once enjoyed are common indicators. Social withdrawal and isolation can also be observed as individuals struggle to cope with their emotions. Treatment for situational depression often involves a combination of therapeutic approaches, depending on the individual’s needs and the severity of their symptoms. Psychotherapy, particularly cognitive-behavioral therapy (CBT), is a common intervention. CBT helps individuals identify and challenge negative thought patterns, develop coping strategies, and gradually regain a sense of emotional stability. Support groups and counseling sessions can also provide a safe space for sharing experiences and learning from others facing similar challenges. The duration of situational depression varies depending on factors such as the nature of the triggering event, individual resilience, and the effectiveness of treatment. In many cases, situational depression tends to diminish as time passes and the individual adapts to their changed circumstances. However, if the symptoms persist or worsen over an extended period, it’s crucial to seek professional help to prevent the development of chronic depression. Overall, understanding situational depression involves recognizing its link to specific life events and acknowledging the profound impact it can have on an individual’s emotional well-being. Timely intervention through therapy, counseling, and support can help individuals navigate the challenging emotions associated with situational depression and facilitate their journey toward healing and recovery. What Is Situational Depression? Situational depression, although not formally recognized as an independent mental health diagnosis, falls under the category of adjustment disorders. Adjustment disorders encompass a range of emotional and psychological challenges that arise in response to a significant life event, such as trauma or a major life change. These disorders can hinder an individual’s ability to effectively adapt to their altered circumstances and can lead to various emotional disturbances. In the context of situational depression, this subtype of adjustment disorder occurs as a result of a specific triggering event that leaves an individual grappling with persistent feelings of distress, sorrow, or bereavement. Unlike other types of depression, situational depression tends to be more short-lived and closely linked to the event that precipitated it. However, its impact on an individual’s emotional well-being can still be profound, affecting their daily functioning and overall quality of life. Greg Simon, MD, MPH, a distinguished psychiatrist based in Washington and affiliated with Kaiser Permanente, notes that situational depression is closely associated with events that induce chronic stress, emotional turmoil, or grief. The uniqueness of this type of depression lies in its transient nature, often subsiding as the individual comes to terms with the event or finds ways to cope effectively. Unlike clinical depression, which may have a more complex interplay of genetic, biological, and environmental factors, situational depression is more directly linked to a triggering circumstance. Navigating situational depression often requires a multifaceted approach that addresses both the emotional distress caused by the triggering event and the development of healthy coping mechanisms. Psychotherapy, especially cognitive-behavioral therapy (CBT), can be effective in helping individuals reframe negative thought patterns and develop adaptive strategies to manage their emotions. Additionally, support groups and counseling can provide valuable outlets for sharing experiences and finding solace among individuals who have faced similar challenges. The duration of situational depression can vary widely, influenced by factors such as the nature of the triggering event, the individual’s resilience, and the effectiveness of interventions. While some individuals may find relief relatively quickly as they process their emotions, others might require more extended periods to regain emotional equilibrium. It’s essential for individuals experiencing situational depression to recognize when their distress persists beyond what is typical for adjustment following the triggering event. Seeking professional help can aid in preventing the transition to chronic or more severe forms of depression. In summary, situational depression, categorized as an adjustment disorder, emerges in response to a specific event that generates emotional upheaval and distress. While it lacks the enduring nature of clinical depression, situational depression’s impact on an individual’s well-being is significant. Acknowledging the connection between the triggering event and the ensuing emotional distress is crucial for seeking appropriate therapeutic interventions and support. Common Causes Situational depression, as the term implies, stems directly from stressful or traumatic situations. Such situations can encompass a range of experiences, including: 1. Coping with the loss of a loved one 2. Facing job loss or unemployment 3. Navigating the challenges of divorce or the end of a romantic relationship 4. Receiving a significant medical diagnosis or undergoing surgery 5. Confronting other scenarios that induce intense stress It’s important to note that situational depression can also arise from any circumstance that triggers heightened levels of stress. While not everyone who undergoes a traumatic event will develop situational depression, individuals who are already predisposed to classic depression

Jul 01

7 Medications That Can Cause Dry Eyes

A surprising number of over-the-counter and prescription meds can cause dry eyes. Insufficient tear production can lead to sensations of dryness, grittiness, burning, or stinging in the eyes, among other discomforts. Dry eye syndrome, a chronic condition surpassing transient dry eye episodes, can arise from various factors, including potential medication-induced effects. This prompts consideration: could the medications one consumes be contributing to the issue? Often, individuals utilizing both over-the-counter and prescription drugs remain unaware of the substantial impact that common pills, sprays, drops, and liquids may have on depriving the eyes of necessary moisture. An array of medications, ranging from cold remedies to prescription heart medications and allergy treatments, can trigger dry eye symptoms. For individuals undergoing multiple medication regimens, the risk to ocular health becomes even more pronounced. Stephanie Crist, Pharm.D., an assistant professor of pharmacy practice at St. Louis College of Pharmacy in Missouri, emphasizes that the cumulative effect of multiple medications can intensify the potential threat to the eyes. In the event that any of your medications appear to be contributing to eye dryness, it is advisable to engage in a dialogue with your healthcare provider. This conversation can pave the way for discovering strategies to alleviate discomfort and preserve ocular health. Antihistamines and Dry Eyes Substances like Flonase (fluticasone), Allegra (fexofenadine), Claritin (loratadine), Zyrtec (Cetirizine), and Benadryl (diphenhydramine) belong to the category of antihistamines. These compounds function by obstructing the action of histamine, a chemical that the body releases in its response to allergens. Antihistamines play a crucial role in alleviating symptoms stemming from allergies and colds, effectively addressing issues like sneezing, itching, watery eyes, and a runny nose. Nonetheless, their impact extends to the eyes, where they can influence the natural tear film responsible for maintaining ocular moisture. A noteworthy aspect of this situation is the similarity in symptoms between dry eyes and allergies, which can lead to confusion. As highlighted by Steven Maskin, MD, the medical director of the Dry Eye and Cornea Treatment Center in Tampa, Florida, the sensation of scratchiness and grittiness due to a lack of watery tears might prompt introspection. Individuals experiencing these sensations could consider whether recent consumption of a medication like Benadryl or other allergy-related medications triggered their dry eye symptoms, particularly if they had initially taken these medications in response to sneezing or other allergy indications. Nasal Decongestants The comfort provided to a congested nose might not extend the same gentleness to the eyes. Over-the-counter decongestants serve as the remedy of choice for alleviating symptoms related to colds, the flu, hay fever, and sinusitis. These medications function by constricting the blood vessels within the nasal membranes, effectively reducing the blood flow to swollen nasal tissues. This mechanism facilitates improved airflow through congested nasal passages. Available in various forms such as pills, liquids, and nasal sprays, nasal decongestants are marketed under diverse brand names, containing active ingredients like phenylephrine, pseudoephedrine, and oxymetazoline. However, akin to antihistamines, decongestants share the propensity to diminish tear production. Some products found on pharmacy shelves even combine the effects of an antihistamine and a decongestant, thereby posing a dual challenge to ocular health. Blood Pressure Lowering Drugs Individuals undergoing prescription treatments to manage blood pressure and address specific cardiac conditions might also encounter the issue of dry eyes. For instance, medications known as beta-blockers are employed to decelerate heart rate, diminish the vigor of heart muscle contractions and relax blood vessel constriction. Nonetheless, these medications are believed to reduce the sensitivity of the cornea, the translucent front surface of the eye. This alteration can subsequently diminish the trigger that prompts tear glands to release the necessary moisture. Dr. Maskin further elucidated this phenomenon. Another category of blood pressure-regulating drugs, diuretics, commonly referred to as water pills, also play a role in the occurrence of dry eyes. Drugs like Microzide (hydrochlorothiazide) and Lasix (furosemide) encourage increased urine excretion by the body, effectively facilitating the removal of excess water from both the body and the eyes. Antidepressant, Antipsychotic, and Parkinson’s Medications Elavil (amitriptyline), categorized as a tricyclic antidepressant, and thioridazine, commonly prescribed for managing schizophrenia, are part of a class of medications exhibiting anticholinergic effects. These substances impede the transmission of specific nerve signals and consequently give rise to particular side effects, including the occurrence of dry eyes. Similarly, Artane (trihexyphenidyl), utilized to counteract stiffness, tremors, and spasms characteristic of Parkinson’s disease, also possesses anticholinergic properties. Dr. Maskin clarifies that under typical circumstances, a healthy nerve detects the presence of eye dryness and initiates a signal relay that progresses until it reaches its intended destination, triggering the release of tears. However, when this communication network experiences disruption, the message remains undelivered, ultimately culminating in the development of dry eye symptoms. Even prominent medications such as Zoloft (sertraline) and Paxil (paroxetine), belonging to a distinct category of antidepressants known as selective serotonin reuptake inhibitors (SSRIs), can contribute to the onset of dry eye discomfort. Hormone Therapy and Oral Contraceptives Hormone therapy introduces a complex interplay with dry eye symptoms. Individuals undergoing hormone therapy for managing menopausal effects, particularly in cases of using estrogen as a standalone treatment, face an elevated risk of experiencing dry eyes. Among post-menopausal individuals, those who exclusively utilized estrogen replacement therapy witnessed a 70% heightened susceptibility to dry eye disease. Meanwhile, those opting for a combination of estrogen and progesterone encountered a 30% increased risk of developing dry eyes. Similarly, hormonal shifts attributed to the use of birth control pills can also contribute to the onset of dry eye symptoms. The employment of birth control pills correlates with a heightened SANDE score—an indicator of dry eye symptoms, with elevated scores indicating a greater likelihood of experiencing dry eyes. Dr. Maskin elaborates on the intricate connection between hormones and ocular dryness, acknowledging that the precise relationship remains unclear. He suggests that estrogen might exert adverse effects on the oil-producing glands within the eye. Furthermore, estrogen could potentially impact the aqueous, or water-based, layer of the tear film, thereby contributing to dry eye

Jul 01

Symptoms of Oppositional Defiant Disorder and How It’s Treated

ODD is a behavioral disorder experienced by some children. Many children exhibit occasional oppositional and defiant behaviors, which can be considered a part of normal developmental processes. However, in cases where a child consistently engages in a pattern of behaviors such as arguing, displaying anger, resisting authority figures including parents and adults, and demonstrating malice towards others, it could indicate the presence of oppositional defiant disorder (ODD). ODD falls within the category of disruptive behavior disorders (DBD), a collection of conditions characterized by behaviors that disrupt the normal functioning of individuals and their surroundings. The American Academy of Child & Adolescent Psychiatry has reported that as much as 16% of children and adolescents are affected by ODD. Here is an overview of essential information concerning this specific mental health condition. Symptoms of Oppositional Defiant Disorder Psychiatric practitioners utilize The Diagnostic and Statistical Manual of Mental Disorders (DSM-5) to aid in determining whether an individual’s symptoms align with the criteria for making a psychiatric diagnosis. In the context of oppositional defiant disorder (ODD), these criteria encompass an ongoing pattern of angry and irritable mood, contentious and resistant behavior, and a propensity for vindictiveness, all persisting for at least six months. An irritable mood entails instances where a child frequently loses their temper and becomes overly sensitive or easily provoked by others. Demonstrating argumentative behavior involves engaging in conflicts with adults or authoritative figures, often with the intention of deliberately provoking or unsettling them, as well as shifting blame to others for their own errors or misconduct. The vindictiveness criteria are met when an individual exhibits spiteful or vengeful actions on at least two occasions within the previous six months. Dr. Margaret Seide, a psychiatrist based in Maryland, expounds on ODD: “ODD refers to a consistent pattern of pervasive negative mood and disruptive conduct observed in children aged at least six years. These individuals may display irritability, impulsiveness, and frequent, seemingly unwarranted bouts of anger. Additionally, they can manifest vindictive tendencies, engage in frequent arguments, and readily defy rules, often with little regard for others or social norms. Their behavior can verge on recklessness and disregard for societal conventions.” The term “defiance,” inherent in the disorder’s name, denotes a persistent challenge to or struggle with authority. Dr. Seide highlights its significance: “Defiance is perhaps the most prevalent and consequential symptom. Regardless of one’s talents or physical abilities, the inability to follow instructions or adhere to regulations can severely impede progress in life.” This poses substantial challenges for individuals with ODD. Dr. Seide emphasizes, “Achievement largely hinges on the capacity to regulate emotions within the framework of laws and guidelines. Flourishing and reaching one’s full potential rely on tolerance for frustration and respect for hierarchical structures. What other children adhere to effortlessly becomes a substantial hurdle and source of strife for a child grappling with ODD.” Children afflicted by ODD may resort to bullying peers as a means to integrate themselves into play and social interactions. Dr. Seide clarifies, “For a child with ODD, their rebellion and reluctance to conform to unspoken codes of civility, sharing, and turn-taking hinder their ability to thrive among peers. They are denied the sense of belonging crucial to social maturation and competence. The genuine acceptance that peers extend is elusive to them.” In summary, ODD presents a complex array of symptoms rooted in disruptive behaviors, affecting emotional regulation, adherence to norms, and social integration. Who Develops ODD ODD is distinctly categorized as a childhood disorder and lacks a defined classification for adults. Primarily, ODD diagnoses are applicable to toddlers and young school-aged children, as highlighted by Gayani DeSilva, MD, a psychiatrist and author based in California. Dr. DeSilva emphasizes the necessity of comprehensive psychiatric assessments to uncover the underlying factors driving oppositional and defiant behaviors. Potential contributors could encompass instances of child abuse, inconspicuous sleep disorders, or even learning disorders. According to the American Academy of Child & Adolescent Psychiatry, ODD typically emerges during the preschool or early elementary school years. Among younger children, boys tend to be more frequently affected than girls. However, within the realm of school-age children and adolescents, an equitable distribution between genders becomes more apparent. Although ODD can manifest in adults, occurrences are exceedingly rare. Dr. Seide underscores the strong link with childhood, stating, “This condition’s association predominantly lies in childhood. In cases where an individual received a diagnosis during childhood and persists in displaying symptoms into adulthood, the diagnosis might extend into adulthood as a continuation.” Mental health experts lean towards a cautious approach when addressing the factors contributing to ODD development. Explaining the complexity of its origins, Dr. Seide asserts, “The genesis likely involves a blend of brain chemistry, genetic predispositions, and home environment influences. Notably, children with ODD often show a higher likelihood of exposure to parental styles marked by severity or neglect within their domestic setting, hinting at a connection.” Dr. DeSilva reiterates the importance of thorough evaluations for young individuals, affirming, “Typically, toddlers and young school-aged children qualify for an ODD diagnosis. A comprehensive psychiatric evaluation is necessary to find out what is driving the oppositional and defiant behaviors. There may be child abuse, a sleep disorder that is not obvious, or even a learning disorder.” In summary, ODD stands as a disorder primarily associated with childhood, with potential contributors stemming from a combination of biological, genetic, and environmental elements. Its rarity in adults further underscores its foundational ties to early developmental stages. How ODD Is Diagnosed In the process of diagnosing ODD, Dr. Seide emphasizes the importance of assessing whether the identified behaviors are pervasive across various settings. For instance, if a child exhibits ODD symptoms primarily at home but demonstrates comparatively well-behaved conduct at school, this may suggest a potential issue within the home environment rather than solely within the child. Additionally, Dr. Seide underscores the significance of ruling out other conditions that can mimic ODD, such as attention deficit disorder (ADD), depression, or autism spectrum disorder. Dr. DeSilva advocates for reserving an ODD

Jul 01

Depression Rates Are Higher Than Ever—Experts Say These 5 Things Need to Change

FAST FACTS According to the latest findings from Gallup, depression rates have reached an all-time high in the United States, revealing a concerning trend. The recent Gallup poll shows that 29% of Americans have received a depression diagnosis at least once in their lifetime. This represents a significant increase of almost 10 percentage points since 2015, making it the highest recorded rate in Gallup’s data history. Of particular concern is the impact of depression on specific demographic groups. The data suggests that younger individuals aged 18 to 29 (34.3%) and those between 30 to 44 (34.9%) experience higher depression rates than those older than 44. Additionally, women are disproportionately affected, with more than one-third (36.7%) reporting having experienced depression at some point in their lifetime. Experts believe that the rise in depression rates can be attributed, at least in part, to societal factors such as isolation and loneliness. Elisabeth Gulotta, a licensed mental health counselor and founder of NYC Therapeutic Wellness, highlights that modern society’s increasing isolation and disconnection play a significant role in contributing to these alarming statistics. She emphasizes that human connection and meaningful relationships are crucial for mental well-being, and the lack thereof may be exacerbating the problem. To address the growing mental health challenges, it is essential to promote a more connected and supportive society. This could involve encouraging meaningful social interactions, fostering a sense of community, and increasing awareness about mental health issues. By working together, we can create a healthier and more empathetic environment for everyone, which may ultimately help reduce depression rates and improve overall well-being. Why Are People More Depressed Now? While the pandemic undoubtedly contributed to the increase in depression rates, mental health experts have identified several other significant factors at play, including rising loneliness and the impact of social media. According to Mark Debus, a licensed clinical social worker and behavioral health clinical manager at Sedgwick, genetics, biochemistry, environmental stressors, and individual personality differences also play roles in the development of depression. Certain vocations can also be associated with higher depression rates. Professions that entail regular exposure to daily trauma or repetitive traumas, such as first responders, law enforcement, medical staff, teachers, and social workers, may experience more significant effects on their mental health. The early signs of depression often emerge in a person’s mid-twenties, as highlighted by Laura Erickson-Schroth, a psychiatrist and chief medical officer for The Jed Foundation. Unfortunately, mental health conditions frequently go undiagnosed for years due to stigma, lack of access to care, and other barriers. Dr. Erickson-Schroth also emphasized that attributing the higher depression rates solely to a growing openness to discuss mental health would be a mistake. There are other critical factors to consider, such as social isolation, unmet essential needs, and limited access to mental healthcare, which contribute significantly to people’s struggles. Elisabeth Gulotta, a mental health expert, described the current situation as “relational poverty.” The combination of the COVID pandemic and the influence of technology has eroded meaningful connections, leading to increased feelings of isolation and separation. Despite the apparent presence of technology and social media, society remains disconnected at a fundamental level, impacting overall mental health. Addressing the rising depression rates requires a comprehensive approach that considers various contributing factors. Improving access to mental healthcare, combating social isolation, and fostering meaningful connections are all essential steps toward creating a more mentally healthy and supportive society. By recognizing and addressing these complex issues, we can work together to improve mental well-being and build a more resilient community. Health Disparities and Depression Rates According to Ling Lam, a lecturer at Santa Clara University’s School of Education and Counseling Psychology, healthcare disparities and barriers to access can significantly increase the risk of depression. Consequently, these factors may also contribute to the current rise in depression rates. Dr. Erickson-Schroth emphasized that youth of color are facing particularly challenging times, with American Indian/Alaska Native youth having the highest rates of suicide among all racial or ethnic groups, and the suicide rate for Black youth having more than doubled over the past decade. To address these alarming trends, it is essential for the country to focus on systemic factors that influence these numbers. One crucial step is to work towards reducing racial discrimination and violence while simultaneously improving access to culturally competent mental healthcare. By creating a more inclusive and supportive environment, individuals from all backgrounds will feel safer and more comfortable reaching out for help when they need it. Addressing the root causes of healthcare disparities and working to provide equitable access to mental health services will be key to reducing the impact of depression on vulnerable populations. This requires a collaborative effort from policymakers, healthcare providers, and communities to create positive change and promote mental well-being for all. How Can We Lower Depression Rates in the U.S.? Addressing the rising trend of depression requires collective efforts at the societal level. Experts emphasize the significance of enhancing social connections and ensuring access to essential needs as vital steps in this endeavor. According to Dr. Erickson-Schroth, improving people’s lives is the most crucial tool in reducing depression rates. This can be achieved by fostering a sense of community and promoting meaningful social connections. When individuals feel supported and connected, it can significantly mitigate feelings of isolation and loneliness, contributing to better mental well-being. Furthermore, ensuring access to essential needs, such as adequate healthcare, stable housing, nutritious food, and education, is critical in addressing the root causes of depression. When these fundamental needs are met, individuals are better equipped to cope with life stressors and are less vulnerable to mental health challenges. Another essential aspect is identifying and addressing sources of stress in society. By implementing measures to reduce stressors related to work, education, finances, and other aspects of life, we can create a more supportive environment that fosters mental resilience. Taking a closer look, experts suggest several strategies to reduce rising depression rates in the United States. Nurture Social Connection At the forefront of reducing the

Jul 01

Coastal Bend Blood Center to host annual ‘Need for Life’ Blood Drives

CORPUS CHRISTI, Texas — The Coastal Bend Blood Center is teaming up with Mattress Firm South Texas to host the annual “Need For Life” Blood Drives. There is a huge need for blood as there has been low blood collections over the last few months, according to CBBC officials. The Coastal Bend Blood Center also told us it’s more important now than ever to restock their shelves in preparation of the Labor Day holiday. “As always, please if you are well and healthy and can spare about 35 minutes of your time, please do so,” CBBC spokesperson Ashley Ramirez said. “We are in need of blood every single day, the need for blood is constant, and unfortunately, it never decreases — but blood donations do, so if you can spare that time please please consider doing so.” There will be two blood drives on Saturday: From 9 a.m. to 5 p.m. at the Mattress Firm on Moore Plaza And 10 a.m. to 2 p.m. at the Mattess Firm at 5 Points in Calallen. For the latest local news updates, click here, or download the KRIS 6 News App.

Jul 01

Connecticut Red Cross celebrates formal end of blood donation restrictions on LGBTQ+ men

In May, the U.S. Food and Drug Administration (FDA) issued a new policy allowing more LGBTQ+ men to donate blood, reversing 1980’s era restrictions. WETHERSFIELD, Conn. — The Connecticut Red Cross celebrated the formal end of blood donation restrictions previously imposed on men who have sex with other men. “I knew I would be one of the first when the day came,” said Paul Shipman, while giving blood Friday. Shipman couldn’t wait to sign in for his donation appointment at the Wethersfield Community Center. “I’m proud to be here and say, I’m a gay man and I’m married and I’m delighted to be able to join the rest of the community,” Shipman said. “This to me is like voting. This is something everyone should do.” Until just a few weeks ago, Shipman was not allowed to give blood. “It doesn’t matter what your sexual orientation is, the blood is just as safe as anyone who walks through our doors,” explained Mario Bruno, Red Cross Regional CEO. In May, the U.S. Food and Drug Administration (FDA) issued a new policy allowing more LGBTQ+ men to donate blood, reversing restrictions put in place during the HIV/AIDS crisis of the early 1980s. On August 7, the American Red Cross implemented the new rule. “It’s about damn time,” John Merz, CEO of Advancing CT Together, said. Merz said the U.S. has been screening its blood supply for nearly 40 years, believing this rule change is a long time coming. “Folks like me, who could have been donating blood, were banned from it simply because of a label that we identified ourselves under,” he said. Some state and federal lawmakers, who pushed for the FDA change, joined Shipman and other first-time donors Friday. “There’s no fact-based reason to deny those donors the opportunity to save lives and every blood donation saves three lives,” said U.S. Sen. Richard Blumenthal, (D-CT). Sign up for the FOX61 newsletters: Morning Forecast, Morning Headlines, Evening Headlines The Red Cross – which collects 40% of all blood in the country – is now using a more inclusive screening process with an individual risk assessment to determine who is eligible to give blood. “Their blood is no different,” Blumenthal said. “It is equally helpful and equally necessary to save lives.” Saving lives is exactly what Shipman is hoping to do. “I will be back,” he said after finishing his donation Friday. “I’ll be eligible again October 13, so I will be making an appointment.” Emma Wulfhorst is a political reporter for FOX61 News. She can be reached at [email protected]. Follow her on Facebook, X and Instagram. Have a story idea or something on your mind you want to share? We want to hear from you! Email us at [email protected] HERE ARE MORE WAYS TO GET FOX61 NEWS Download the FOX61 News APP iTunes: Click here to download Google Play: Click here to download Stream Live on ROKU: Add the channel from the ROKU store or by searching FOX61. Steam Live on FIRE TV: Search ‘FOX61’ and click ‘Get’ to download. FOLLOW US ON X, FACEBOOK & INSTAGRAM

Jul 01

Tri-State Area blood banks begin accepting donations from gay, bisexual men

Tri-State Area blood banks begin accepting donations from gay, bisexual men – CBS New York Watch CBS News Tri-State Area blood banks are implementing new donation guidance from the FDA. As CBS New York’s Tony Aiello reports, it removes barriers for gay and bisexual men who want to donate blood. Read more: https://cbsloc.al/3QLKVTN View CBS News In Be the first to know Get browser notifications for breaking news, live events, and exclusive reporting. Not Now Turn On