The Callaway County Extended Employment Center is partnering with the American Red Cross to host a blood drive on Monday. Marla Mason, general manager at the Callaway County Extended Employment Center, said appointments to donate blood can be reserved online. Walk-in appointments will also be accommodated. Appointments for regular blood donation and Power Red donation are available. Blood donors will receive a free t-shirt and a $10 Amazon gift card, Mason said. The blood drive will be 10 a.m. to 2 p.m. Dec. 4 at the Callaway County Extended Employment Center, 2611 N. Bluff St. in Fulton. To reserve an appointment to donate blood, visit https://www.redcrossblood.org/give.html/find-drive.
Month: November 2023
It was sheer barbarism and savagery that brought an end to France’s brutal 132-year-long occupation of Algeria, and it is the same destructive force that will end Israel’s war against the Palestinians in Gaza. At the moment, though, it is clear that Israel has learnt nothing from France’s blood-soaked occupation of Algeria. Like the ongoing fight for the liberation of Palestine from Zionist rule, history still has much to write about the atrocities committed by French colonialists in Algeria during the occupation from 1830 to 1962. At least five million people were killed and hundreds of thousands were wounded in the struggle for independence. In 1959, French President Charles de Gaulle declared that the Algerians had the right to determine their own future. Despite so-called terrorist acts by French Algerians opposed to independence and an attempted coup in France by elements of the French army, an agreement was signed in 1962, and Algeria was finally independent. Algeria is still known as the Land of a Million Martyrs, a figure far too conservative, according to those who live in Africa’s largest country today. As for France, it has learned little or nothing from its legacy as a brutal occupier and the terrorism that its occupation of Algeria fostered. READ: Erdogan tells UN chief that Israel must face international courts over Gaza crimes I now wonder if Gaza has reached its “Algeria moment” in a 75-year conflict which ultimately created the conditions for the 7 October attack against the brutal and rapacious Zionist occupation state. The scale of the attack has traumatised Israel and many within the Jewish diaspora. The ferocity with which the Hamas-led resistance fighters hit back has destroyed the arrogance and confidence of the Zionist State and its supporters in the same way that 9/11 knocked the stuffing out of the American swagger. Sadly, neither the US nor Israel took the time to catch their breath and ask why these events happened. The question was never asked and America’s response, as Israel’s will, went on to radicalise a generation of young people around the world. The so-called “War on Terror” crushed any semblance of respect for human rights, international law and the Geneva and Vienna conventions. Officially-sanctioned kidnapping and torture gave us the new 21st century euphemisms of “extraordinary rendition” and “enhanced interrogation techniques”. To their eternal shame, European countries looked the other way as the US intelligence agencies installed black sites for ghost detainees and tortured them on an industrial scale. US President George W Bush probably had no idea that he was about to embark on America’s longest ever war in his blind fury to get revenge by attacking the Taliban regime in Afghanistan, which, incidentally, played no part in 9/11. Twenty years and four presidents later, the war ended as spectacularly as it had started, when the biggest and most powerful army in the world fled, Vietnam style, and the Taliban returned to power in Kabul. READ: Aid entering Gaza is 5% of what entered before 7 October There are fears that Israel has been lured into a similar trap by Hamas, which is believed to have invested two years in planning the attack on the apartheid occupation state. The raging fury which erupted in Tel Aviv on 7 October was entirely predictable and probably had a lot to do with the catastrophic intelligence failure by the Israeli military which was caught napping by the audacious, daring breakout from the Gaza concentration camp by Hamas fighters belonging to the movement’s military wing, Al-Qassam Brigades. Israeli Prime Minister Benjamin Netanyahu was seen strutting around in his army fatigues like some aging Volodymyr Zelenskyy, threatening revenge of Biblical proportions on the Palestinian people. At times he still seems confused about who he is waging his bitter, vindictive war against: Palestine, its women and children, or Hamas; or all of them. One unhelpful government minister expressed the desire to “nuke” Gaza — he let the cat out of the bag and basically confirmed that Israel has nuclear weapons — so it’s little wonder that no one is focused on an end game. We need to know who will govern Gaza after the war and how it will be governed. This should be decided by the people of Palestine, not corrupt politicians in Israel and the West. World leaders have been bullied into silence while Israel commits war crimes as a matter of routine, bombing hospitals, UN schools and civilian infrastructure, and cutting off all water and power supplies to the civilian population. Thank God Queen Rania of Jordan stood up and spoke out for the Palestinian people; she exposed the “strongmen” across the Arab world as the cowards that they are. The cack-handed Americans took “shock and awe” to Iraq, leaving us incredulous that no one seemed to have given any thought to what was going to happen the day after the war. But no one had and the dire consequences remain today, along with one million widows and orphans dependant on humanitarian aid. The anger vented by film and TV writer Armando Iannucci was palpable when he wrote about this earlier in the year. Without a thought for the future, the US sacked all of Iraq’s civil servants, everyone in the Ba’ath Party, and anyone in charge of the civil police. It was all done in such a rush that no one thought about disarming the military, leaving hundreds of thousands of angry Iraqi army veterans to roam around with their weapons. READ: Israel freed captives testify to being treated ‘extremely well’ by Hamas I’ve seen the work that Hamas does in Gaza. Its military wing came along after its social, political and welfare arms were established. You only have to be there for a few days to understand how the country works, and that it couldn’t work without Hamas. The leadership has as many PhDs in government as any Western cabinet, and is loved by the people because they live alongside them and share their difficulties,
The announcement on Tuesday that the Food and Drug Administration was investigating whether CAR-T immunotherapy had itself caused blood cancers initially appeared to be a significant blow to one of the brightest spots in cancer care. But experts quickly cautioned that risk of this complication is probably minuscule compared to the known risk of secondary cancers from other cancer therapies like chemotherapy and radiation. They noted that CAR-T cells are immune cells that are genetically engineered to fight cancer, and that such genetic modifications were long thought to carry a risk of causing a second, new cancer in patients. The surprise, in a way, is that since CAR-T was first invented more than 10 years ago, that risk had remained just theoretical. advertisement “There’s been a requirement for long-term follow up. I think this is why we’re all surprised. As far as I think any one of us knew, it’d never happened with any of the FDA-approved CAR-Ts,” said Marcela Maus, a cell therapy researcher at Mass General Cancer Center. Get unlimited access to award-winning journalism and exclusive events. Subscribe
KANSAS CITY, MO – A commonly used therapy for patients with type 2 diabetes, heart failure and kidney disease known as sodium-glucose cotransporter inhibitor (SGLTi), is showing promise for decreasing the risk of developing many common age-related conditions, including cardiovascular disease, cancer, dementia, fatty liver, and gout according to researchers at Saint Luke’s Mid America Heart Institute and University of Missouri-Kansas City. This is the first scientific paper to formally propose SGLTi as an agent that may slow aging at the cellular level and improve longevity. An evolving body of research shows that SGLTi, a once-daily well-tolerated pill, reduces risk for many of the most prevalent and lethal chronic diseases, and reduces hospitalizations. “Slowing aging tends to prevent disease and improve life expectancy much better than working on treatments for individual diseases,” said James O’Keefe, MD, the study’s lead author and director of preventive cardiology at Saint Luke’s Mid America Heart Institute. “This is the first therapy with a large amount of clinical data in humans to suggest that it that may indeed slow the pace of aging.” The innate aging process is the most important risk factor for the majority of serious chronic diseases and premature death. Aging results in the progressive loss of normal functions, beginning at the cellular level and progressing to affect organs, predisposing to disease, weakness, frailty and immobility. Aging increases the risk of developing a wide range of illnesses including cardiovascular, metabolic, neurodegenerative, infectious, and neoplastic diseases. SGLTi has been shown to reduce risk of many of these illnesses including heart failure, chronic kidney disease, atrial fibrillation, cancer, gout, emphysema, neurodegenerative disease/dementia, non-alcoholic fatty liver disease, atherosclerotic disease, and infections. SGLTi are a unique class of drugs that block reuptake of filtered glucose in the kidney. This simple action alters nutrient sensing in the body in a way that stimulates autophagy—cellular housekeeping that rejuvenates cells and organs, leading to reduced risk of disease and hospitalization. Not only do studies suggest SGLTi reduces the risk of developing common conditions, but also that they improve overall life expectancy and reduce the risks of death from cardiovascular disease and cancer. “Along with a healthy diet and an active lifestyle that involves plenty of exercise, this drug might help lower the risk for diseases across the board,” said Dr. O’Keefe. “Generic SGLT2 inhibitors are becoming available to make this previously expensive class of drugs affordable for almost everyone.” Read the full article SGLT inhibitors for improving healthspan and lifespan in Science Direct: Progress in Cardiovascular Diseases. Saint Luke’s Mid America Heart Institute, a part of Saint Luke’s Health System and a teaching affiliate of the University of Missouri-Kansas City School of Medicine, is one of the distinguished cardiovascular programs in the country. Its legacy of innovation began more than 40 years ago when it opened as the nation’s first freestanding heart hospital. Since then, the Heart Institute has earned a global reputation for excellence in the treatment of heart disease, including interventional cardiology, cardiovascular surgery, imaging, heart failure, transplant, heart disease prevention, cardiometabolic disease, women’s heart disease, electrophysiology, outcomes research, and health economics. Saint Luke’s Mid America Heart Institute cardiologists offer personalized cardio-oncology care, where our experts diagnose and treat heart conditions in patients who have been or are being treated for cancer. With more than 100 full-time, board-certified cardiovascular specialists on staff, Saint Luke’s Mid America Heart Institute offers one of the country’s largest heart failure and heart transplant programs, has the largest experience with transcatheter aortic valve replacement in the Midwest, and is a global teaching site for the newest approaches in coronary revascularization. The Heart Institute’s cardiovascular research program encompasses clinical areas as well as centers of excellence and core laboratories. It continues to serve as one of the four Analytic Centers, along with Duke, Harvard, and Yale, for the American College of Cardiology’s National Cardiovascular Data Registry. Saint Luke’s Mid America Heart Institute is ranked 47th in the nation for Cardiology, Heart & Vascular Surgery by U.S. News & World Report and is the third hospital in the U.S. to achieve Comprehensive Cardiac Center certification from The Joint Commission.
“I’ve been practicing emergency medicine for 25 years, and I have not seen strep throat as frequently as I have in these past six or eight months,” said Dr. Jennifer Stevenson, the head of the emergency department at Henry Ford Medical Center in Dearborn, Mich., in an Oct. 28 NBC report. This report said that the bacterial illness, marked by painful, scratchy throats and high fevers, has been rising for months in parts of the mid-Atlantic and the Southeast. And, unfortunately, no one seems to know why. Since medical providers aren’t required to report strep throat diagnoses to our health department, we don’t know if strep infections are increasing here. But after seeing this report, I think it’s a good time to address this infection that affects several million people a year. Strep throat is caused by a bacterium known as Streptococcus pyogenes, aka group A streptococcus. “Streptococcal bacteria are contagious,” May Clinic says. “They can spread through droplets when someone with the infection coughs or sneezes, or through shared food or drinks. You can also pick up the bacteria from a doorknob or other surface and transfer them to your nose, mouth, or eyes.” Although it primarily affects children ages five to fifteen, strep throat can happen to anyone at any time. Parents of school-aged children or those who are in contact with younger children are more at risk. The Centers for Disease Control and Prevention says it’s “very rare” in children younger than 3. The CDC says that it is more prevalent in the early spring and winter. The bacteria, it seems, flourishes whenever people are in close contact with one another. Places like schools, daycare centers, and military training facilities can be petri dishes for infections. “Strep bacteria may spread, causing infection in the tonsils, sinuses, skin, blood or middle ear,” Mayo says. “It can also lead to inflammatory illnesses, including scarlet fever, inflammation of the kidney, rheumatic fever or poststreptococcal reactive arthritis.” Signs and symptoms may include throat pain that comes on quickly, pain swallowing (one woman said she couldn’t even swallow her spit, it hurt so badly), red and swollen tonsils, sometimes with white patches or streaks of pus; tiny red spots on the area at the back of the roof of the mouth; swollen, tender lymph nodes in the neck; fever, headache, rash, nausea or vomiting (especially in younger children) and body aches. “It’s possible for you or your child to have many of these signs and symptoms but not have strep throat,” Mayo explains. “The cause of these signs and symptoms could be a viral infection or some other illness. That’s why your doctor generally tests specifically for strep throat.” Not only that, it’s also possible for a person to have a strep infection and be contagious but not show any signs or symptoms. After the primary care provider does a physical exam of the patient and believes the symptoms are caused by group A streptococcus, he or she will swab the throat. Then, one of two things will happen. The rapid strep test quickly shows if the bacteria is causing the illness. If that’s the case, the provider will prescribe antibiotics. “If the test is negative, but a doctor still suspects strep throat, then the doctor can take a throat culture swab,” the CDC says. “A throat culture takes time to see if group A strep bacteria grow from the swab. While it takes more time, a throat culture sometimes finds infections that the rapid strep test misses. Culture is important to use in children and teens since they can get rheumatic fever from an untreated strep throat infection.” Strep throat is treated with antibiotics. The benefits include decreasing how long someone is sick, decreasing symptoms, preventing the bacteria from spreading to others, and preventing serious complications. Also, taking antibiotics will help the patient feel better in just a day or two. Two things to note about taking antibiotics: it’s important to take the medicine as directed and to take the whole course. Don’t let the patient stop taking them just because they feel better unless directed by their PCP. And don’t forget to throw away their toothbrush as soon as the infection is gone. Kathy Hubbard is a member of the Bonner General Health Foundation Advisory Council. She can be reached at [email protected].
If 2022 was the year mpox infections exploded globally, 2023 was the year much of the world stopped paying attention. Yet Canadian researchers, in collaboration with scientists working on the ground in hot spots such as Nigeria and the Democratic Republic of the Congo (DRC), are still shining a spotlight on the virus that sparked last year’s unprecedented global outbreak — and one that still seems capable of new surprises. One joint Canadian-DRC research team, co-led by Jason Kindrachuk from the University of Manitoba, has documented what Kindrachuk calls a “massive red flag”: the first known cases of a deadlier strain of mpox spreading through sexual contact. “This is a real concern for us in regard to the potential for the disease to spread broadly,” he said. The World Health Organization (WHO) announced the finding in its latest mpox report, and CBC News has obtained the forthcoming paper in which Kindrachuk — and a team of other Canadian, Congolese and international researchers — further outline a cluster of clade I infections linked to sexual transmission. There are two main forms of mpox virus: clade I and clade II. The global outbreak in 2022 involved clade IIb, which typically leads to milder illness. By year’s end there had been roughly 87,000 infections and more than 100 deaths after the virus spread widely through sexual networks, with the majority of the cases among men who have sex with men. Infections of that form of mpox leads to an array of painful and sometimes debilitating symptoms, including both internal and external lesions, but relatively few deaths. Clade I, in contrast, was long estimated to have a death rate of up to 10 per cent, though the most recent WHO report on an ongoing outbreak in the DRC suggests a case fatality rate of close to five per cent. Until now, it was also thought to spread mainly through close contact, including surface-based transmission. 5 individuals tested positive The paper from Kindrachuk’s team outlines how a Congolese man, identified by WHO as a resident of Belgium, had sexual contact with another person in Europe. After arriving in the DRC, the man then tested positive for clade I mpox, and reported that he had sexual contact with nine additional partners, including six men and three women. Five contacts in total ended up testing positive, and all required outpatient treatment and pain control, the research team reported. Followup investigations also looked at other possible transmission chains involving 120 additional contacts — including other sexual contacts and family members — but none of those individuals developed mpox during 21 days of follow up. “We have a tiny piece of the puzzle suggesting something is different now,” Kindrachuk said, noting the new finding raises fresh questions about just how often sexual transmission is already happening within the DRC. Given the increased disease severity associated with this mpox clade, the researchers stressed sexual transmission could impact broader geographical spread of mpox across both clades of the virus. WHO said another outbreak in the DRC is also being reported, involving multiple cases of mpox among sex workers. These new instances of sexual transmission raise concerns about the rapid expansion of mpox within the country and beyond, given its “internationally mobile” population, the organization continued in its latest report. A child with mpox sits on his father’s lap while receiving treatment at the centre of the International medical NGO Doctors Without Borders in the Central African Republic. The World Health Organization has declared an end to the global public health emergency for mpox, yet some scientists warn there’s still cause for concern. (Charles Bouessel/AFP) DRC experiencing largest annual outbreak The DRC has been particularly hard hit by the deadlier form of mpox this year. It has been linked to more than 12,000 suspected cases and nearly 600 deaths since the start of the year — the highest number of annual cases ever reported in the Central African nation, WHO figures show. Worldwide transmission of the milder clade is still simmering as well. Though WHO ended its emergency designation for mpox in May, and case reporting in many regions has been scaled back since then, hundreds of clade IIb cases were still reported across dozens of countries this fall. More than a year into the global outbreak, burning scientific questions about how mpox operates remain unanswered, while hot spots throughout Africa that have endured outbreaks for years still don’t have access to vaccines. “In Congo this year, there are thousands and thousands of cases of mpox, and not a vaccine dose to be found … it’s such a slap in the face to our colleagues [in Africa],” said Kindrachuk. “We shouldn’t just be responsive when these types of infectious diseases move into our regions or across our borders and start to present a much greater threat.” A patient receives an mpox vaccination at a clinic in southern France in August 2022. While global cases of the virus are now dropping, some scientists warn mpox will remain a global threat, with future outbreaks a near certainty. (Pascal Guyot/AFP/Getty Images) The world only became interested in mpox when cases appeared beyond the African continent, said Toronto-based infectious diseases physician Dr. Isaac Bogoch, who is working on DRC mpox research alongside Kindrachuk. “This [is] an infection that has been recurring and increasing in frequency over the last couple of decades as the smallpox vaccine programs started to wind down,” he said, noting that endemic regions of Africa still lack both vaccines and treatment options. In contrast, many higher-income countries made vaccines and therapeutics widely available during last year’s outbreak. Vaccine campaigns launched throughout Canada used a smallpox/mpox vaccine manufactured by Bavarian Nordic, for instance, and health-care providers here have also prescribed the smallpox treatment TPOXX off-label for mpox patients. WATCH | Mpox infections can mean weeks of pain, isolation: What it’s like to recover from monkeypox 1 year ago Duration 1:57 Featured VideoA Toronto resident shares his experience recovering from monkeypox, while officials and
In a recent breakthrough, doctors have found a potential solution for people experiencing long-term smell problems post-Covid infection — nerve-blocking injection. While some treatments help with the loss of smell, there hasn’t been much success in treating the issue where smells are distorted, a condition called parosmia. People with parosmia may perceive odors differently than they actually are, often experiencing unpleasant or distorted smells even when exposed to familiar scents. Meanwhile, Covid-19 also triggered Anosmia, which is the loss or absence of the sense of smell. Individuals with anosmia are unable to detect or perceive odors. advertisement Anosmia can have a significant impact on a person’s quality of life, affecting their ability to taste food and detect potential dangers, such as spoiled food or gas leaks, by smell. The treatment was safe with very few risks. (Photo: Getty) The study, done with the help of Ear, Nose, and Throat specialists, focused on patients who still had smell issues six months after having Covid-19, despite trying different medicines. The doctors presented their preliminary findings at the annual meeting of the Radiological Society of North America and stated the use of a special technique called CT-guided stellate ganglion block (SGB). This involves placing a small needle near the neck and injecting a numbing medicine into the bundle of nerves. This was done with the help of a CT scan to make sure the needle was in the right place. They also looked for any temporary side effects, like a condition affecting the eyes. The results were promising. Out of 54 people in the study, 59% felt better just a week after the treatment. And for 82% of them, the improvement kept going up even a month later. The report stated that after three months, people who got the treatment reported feeling 49% better on average. Some even got back 100% of their smell! They also found that doing the same treatment on the other side of the neck helped more for some people. Anosmia can have a significant impact on a person’s quality of life. (Photo: AP) “SGB shows promise for patients with long term post-Covid parosmia, and CT provides ideal efficiency and guidance,” the paper read. A temporary side effect called Horner’s syndrome happened in 95% of cases, but it went away within 30 minutes. This showed that the treatment was safe with very few risks. This new treatment seems like a hopeful solution for people who still struggle with distorted smell after having Covid-19. Published By: Sibu Kumar Tripathi Published On: Nov 29, 2023 Trending Reel
Share this article <!– –> BMS will make milestone payments totalling up to $2.2bn, apart from royalty payments based on net product sales, to Avidity. Credit: nitpicker / Shutterstock.com. Avidity Biosciences has entered an international licencing and research partnership with Bristol Myers Squibb (BMS) to discover, develop and market cardiovascular targets in a $2.3bn deal. Avidity will receive an upfront payment of $100m. This comprises $60m to be paid in cash and $40m for the purchase of the company’s common stock. BMS will make milestone payments of $2.2bn to Avidity, apart from royalty payments based on net product sales. Research and development-based milestone payments could be up to $1.35bn. $825m will be paid on meeting commercial milestones. All clinical development, as well as regulatory and commercialisation work linked to this partnership, will be financed by BMS. Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge. View profiles in store Company Profile – free sample Your download email will arrive shortly We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form By GlobalData The companies will work on up to five targets in the cardiovascular field utilising Avidity’s antibody oligonucleotide conjugate (AOC) platform technology. Created to act on the diseases’ root causes, which were previously untreatable with RNA therapies, AOCs merge the monoclonal antibodies’ specificity with the precision of oligonucleotide treatments. The new deal in the cardiovascular field is an expansion of an already existing deal between the companies. Avidity signed a research partnership with BMS subsidiary, MyoKardia, in 2021 to study the potential of AOCs in cardiac tissue. Avidity Biosciences president and CEO Sarah Boyce stated: “We are excited to expand our collaboration with Bristol Myers Squibb, who are world leaders in cardiovascular drug discovery and development. “This strategic collaboration solidifies our commitment to cardiology as we continue to advance our own research and development programmes in cardiac indications.” Avidity’s internal discovery pipeline comprises candidates for the treatment of rare skeletal muscle ailments and cardiac muscle diseases. Three of the company’s rare disease programmes are currently at the Phase I/II clinical trial stage. The latest development comes after BMS received priority review from the US Food and Drug Administration for its Breyanzi (lisocabtagene maraleucel) to treat patients with relapsed or refractory chronic lymphocytic leukaemia or small lymphocytic lymphoma. <!– –> Sign up for our daily news round-up! Give your business an edge with our leading industry insights.
Jakarta (ANTARA) – Yogyakarta has recorded a reduction in dengue cases, dropping below the global incidence rate of 10 per 100,000 population, following the use of Wolbachia-infected mosquitoes, Health Minister Budi Gunadi Sadikin stated on Wednesday. In his Instagram post, he attributed this success to research conducted by Gadjah Mada University. He mentioned that the dengue incidence rate in Indonesia has continued to increase compared to global standards since 1968, despite various interventions carried out by the government, such as fogging, larviciding, and the implementation of the 3M movement. The current dengue incidence rate in Indonesia is 28.5 per 100,000 population. Yogyakarta City, in fact, had previously reached figures of 300 to 400 per 100,000 population, according to Sadikin. The Ministry’s Directorate General of Prevention and Control of Infectious Diseases (P2P) reported that the rate of dengue cases in Indonesia averages between 74,000 to 140,000 per year. Meanwhile, from January to November 2023, dengue cases in Indonesia reached 76,449 patients, with 571 deaths. This figure represents a successful reduction from the number of dengue cases in 2022, which totaled 143,300 patients and 1,236 deaths, thanks to interventions such as fogging, larviciding, the use of mosquito nets, and the 3M plus movement. “Apart from approximately 200 children dying from acute kidney failure, we are also saddened to see thousands of children dying due to dengue. We must replicate the success of Yogyakarta City in saving our children’s lives,” Sadikin remarked. He mentioned that the government had decided to implement the Wolbachia program to suppress the replication of the dengue virus transmitted through the bite of the Aedes aegypti mosquito. “Most children die every year because of dengue. We successfully implemented the Wolbachia program in Yogyakarta,” he noted. The Health Ministry is implementing Wolbachia technology to reduce the spread of dengue hemorrhagic fever in Indonesia. This technology employs a “replacement” method, whereby male and female Wolbachia-infected mosquitoes are released into natural mosquito populations. The objective of this method is to enable female mosquitoes to mate with local mosquitoes, ultimately producing offspring that contain Wolbachia. Related news: Dengue: Govt spends Rp16 billion on Wolbachia trialsRelated news: Disseminating information on Wolbachia method a challenge: official
Introduction The 2021 WHO classification categorizes neuroendocrine neoplasms (NENs) of the lung as a single tumor group, which includes low- and intermediate-grade typical carcinoid (TC) and atypical carcinoid (AC) and high-grade NE carcinomas (NECs), including large cell neuroendocrine carcinoma (LCNEC) and small cell lung cancer (SCLC).1 Combined small cell lung cancer (C-SCLC) is a subtype of SCLC that comprises three types according to the different components combined with SCLC, including adenocarcinoma, LCNEC, and squamous cell carcinoma. Indeed, approximately 5–28% of surgically resected SCLCs are diagnosed as C-SCLCs.2,3 However, limited specimens, such as those obtained for cytology or from a small biopsy, tend to underestimate C-SCLC incidence. The current guidelines for SCLC management do not describe a standard treatment for C-SCLC in detail. Routinely, C-SCLC management consists of multimodality treatment (surgery, radiotherapy, chemotherapy, and immunotherapy) and is often based on SCLC guidelines.4 To date, genomic changes in C-SCLC remain unclear, and RET fusions in C-SCLC have not been reported. The RET proto-oncogene is located on the long arm of chromosome 10 with a length of 60,000 bp and 21 exons.5 The RET gene promotes carcinogenesis primarily by gene fusion, point mutation, and amplification, and is associated with multiple cancers.6 RET fusions have been detected in most papillary thyroid carcinomas and in 1–2% of NSCLCs.7,8 RET fusions involve different fusion partners, with the most common being KIF5B-RET (62–68.2%) and CCDC6-5B (16.8–21%).9–12 Currently, the tyrosine kinase inhibitors (TKIs) selpercatinib and pralsetinib have been approved by the FDA for locally advanced or metastatic solid tumors with RET fusions that have progressed on or following prior systemic treatment.13,14 Furthermore, several strategies and novel targeted drugs are currently under investigation.15 Here, we report for the first time a case of extensive-stage C-SCLC, in which the tumor harbored the KIF5B-RET fusion before first-line therapy and was persistently sensitive to selpercatinib after failed cytotoxic chemotherapy, immunochemotherapy and anlotinib hydrochloride administration. This case highlights the importance of comprehensive molecular testing in C-SCLC for selecting the optimal treatment. Although RET fusion is rare in patients with C-SCLC, its identification and treatment using selective RET inhibitors may contribute to clinical benefits. Case Presentation A 57-year-old never-smoking Asian woman with no significant medical history presented with cough and dyspnea for 2 months. Computed tomography (CT) revealed a mass in her left upper lung (primary lesion, 4.1 cm) with obvious bilateral intrapulmonary and mediastinal lymph node metastases (Figure 1a), without bone, liver, kidney, and brain metastases. Figure 1 Imaging evaluation and detection of serum tumor biomarkers during treatment. (a–g) Sequence of anticancer treatments and the corresponding imaging evaluations. Red arrows indicate the primary tumor, while red asterisks indicate newly developed intrapulmonary metastatic lesions. A remarkable shrinkage of the primary tumor and intrapulmonary metastases was observed after 5 and 14 months of treatment with selpercatinib. (h) Serum CEA and NSE were detected to monitor clinical response during the treatment. Abbreviations: Jan., January; Mar., March; Jul., July; Dec., December; Aug., August; VP-16, etoposide; DDP, cisplatin; T, atezolizumab; Nab-p, nab-paclitaxel; CBP, carboplatin; PCI, prophylactic cranial irradiation; CEA, carcinoembryonic antigen; NSE, neuron-specific enolase. Subsequently, a transbronchial biopsy of the tumor mass in the left upper lobe was carried out, and histological analysis revealed C‐SCLC (Figure 2a) comprising SCLC (Figure 2b) and LCNEC (Figure 2c), without gland formation or keratinization. Immunohistochemistry (IHC) showed positive signals for synaptophysin (Syn, Figure 2d–f), pan-cytokeratin (PCK, Figure 2g–i), and Ki67 (MIB-1, Figure 2j–l), with a high proliferative index of 50% (average for SCLC and LCNEC). Other biomarkers, including napsin A, lymphocyte common antigen (LCA), and desmin were not detected. Finally, the patient was diagnosed with advanced stage (cT2bN2M1a, IVA) lung neuroendocrine carcinoma (combined SCLC and LCNEC) in January 2021. Figure 2 Histological analysis of the transbronchial lung biopsy revealed two different tumor components. (a) Hematoxylin and eosin (H&E) staining showing C-SCLC (combined SCLC and LCNEC, 100×). (b) SCLC is characterized by the presence of diffuse sheets of small round-to-fusiform cells, with scant cytoplasm, and inconspicuous or no nucleoli with finely granular nuclear chromatin. Meanwhile, nuclear chromatin smearing, also termed crushed artifact, is common in SCLC (400×). (c) LCNEC is characterized by large cells, frequent presence of nucleoli and abundant cytoplasm (400×). (d–f) Both the SCLC and LCNEC components were positive for synaptophysin (Syn, 100×, 400×). (g) Different modes of PCK expression in C-SCLC (100×). (h) The so-called dot-like staining pattern of PCK in SCLC (400×). (i) The LCNEC component was diffusely positive for PCK in the cytoplasm (400×). (j–l) Different Ki67 levels were found in both tumor components (100×, 400×). The patient showed progressive disease (PD) after 3 cycles of first-line chemotherapy (cisplatin, etoposide) combined with immunotherapy (atezolizumab), manifested as enlargement of the primary lesion (5.0 cm, Figure 1b). Considering the presence of LCNEC, paclitaxel-albumin combined with carboplatin was applied for second-line chemotherapy while maintaining atezolizumab. Fortunately, the patient achieved a partial response (PR) after four cycles (primary lesion, 2.6 cm; Figure 1c) and received prophylactic cranial irradiation (PCI) subsequently. Then, the patient developed PD during regular follow-up with new intrapulmonary metastases (Figure 1d). Considering the Eastern Cooperative Oncology Group (ECOG) performance status (PS) of the case was 2 and the patient declined further tissue biopsy and chemotherapy, anlotinib hydrochloride, a novel multitarget tyrosine kinase inhibitor, was administered as third-line therapy. However, the lesions grew rapidly and additional metastases occurred (Figure 1e). To examine genetic changes in the tumors, next-generation sequencing (NGS), evaluating 1021 cancer-related genes (Geneplus),16 was performed on treatment-naive tumor and blood specimens after third-line treatment, respectively. NGS data showed that the treatment-naïve tumor from the patient had the KIF5B-RET fusion (41.4%) and RB1 deletion, with blood cell-free DNA (cfDNA) still containing the KIF5B-RET fusion (0.1%). Soon afterwards, the patient was administered 160 mg selpercatinib twice daily and achieved a PR in almost all lesions, including the primary tumor (3.1 cm) and metastatic lesions (Figure 1f). At the time of manuscript preparation, the patient was still taking selpercatinib with a progression-free survival (PFS) surpassing 14 months and ongoing response (primary lesion, 2.8 cm; Figure 1g). No obvious drug-related adverse