Month: October 2023

BOISE, Idaho — 6.8 million people in America donate blood. However, one man has taken a different approach to donating. It’s six in the morning. Most are just waking up or are already getting ready for their day, but Pennsylvania man Vinton Smith is getting ready to donate blood. “When I think about donating blood, I think about the people who will be benefiting from receiving that blood. that motivates me more than anything else,” explained Smith. Smith has taken it upon himself to donate blood in all 50 states. This week’s trip to Idaho marked his 47th state. Smith said the remaining three on his checklist are Nevada, Alaska, and Hawaii. Idaho News 6 spoke with the American Red Cross Idaho District Manager for Donor Services, Stephen Dalmas about his thoughts on Smith’s journey. Dalmas said, “It’s the dedication. It’s the personal mission he has to help other people.” That is what is amazing,” said Dalmas. For the last 35 years, Smith has been donating blood. His first time was his senior year of high school. Smith says that his passion for giving back starts with his parents. Smith explained, “I grew up watching my dad donate blood every two months. I also saw my mother working in the community helping others. I think that idea of helping others was instilled in me as a young boy.” Both men explained that having the ability to donate in today’s world is so important. Smith said, “We may not know what tomorrow may bring. We may not know when we may be the ones who may need to receive blood or platelets. We don’t know when a family member is the one that needs it.” “It is just doing good for someone you might never meet,” said Dalmas Speaking with Dalmas, he said that there is a national blood and platelet shortage here in America and that it is more important than ever to go and donate. You can go to redcrossblood.org to find a blood donation center in your community.

WASHINGTON—Pushing back a black hood to reveal reddened, glowing eyes, Sen. Ron Darkness appeared on CNN Friday to try to garner support for a 1,000-year reign of blood. “In times of great tragedy, we as Americans must do all we can to enact many millennia of death and suffering,” the independent lawmaker from Hades said in an address delivered through all languages at once, reading off a teleprompter operated by Samael, Ruler of Hell, who reportedly left the studio floor peppered with unconscious and bleeding CNN crew members. “The harrowing images and rising death tolls coming out of the Middle East are, frankly, child’s play. Viscera must flow down every street. The oceans must blacken with blood and terror. We must crucify ourselves at the altar of death. That is why I am announcing my run for president.” Sen. Darkness went on to plead for all belligerents in the world’s conflicts to not relent until a 100% global casualty rate had been reached. This Week’s Most Viral News: October 13, 2023 Off English

Oct. 13, 2023 6:00 am ET Listen (2 min) More period-care brands are slowly replacing the blue liquid that has long been ubiquitous in the category’s advertising with more realistic red alternatives, despite pushback from some consumers and media companies. Copyright ©2023 Dow Jones & Company, Inc. All Rights Reserved. 87990cbe856818d5eddac44c7b1cdeb8

If you have ever gotten a vaccine or received an intravenous drug and did not come down with a potentially life-threatening fever, you can thank a horseshoe crab (Limulus polyphemus). How can animals that are often called living fossils, because they have barely changed over millions of years, be so important in modern medicine? Horseshoe crab blood is used to produce a substance called limulus amebocyte lysate, or LAL, which scientists use to test for toxic substances called endotoxins in intravenous drugs. These toxins, produced by bacteria, are ubiquitous in the environment and can’t be removed simply through sterilization. They can cause a reaction historically referred to as “injection fever.” A strong concentration can lead to shock and even death. Identifying LAL as a highly sensitive detector of endotoxins was a 20th-century medical safety breakthrough. Now, however, critics are raising questions about environmental impacts and the process for reviewing and approving synthetic alternatives to horseshoe crab blood. We study science, technology and public policy, and recently published a white paper examining social, political and economic issues associated with using horseshoe crabs to produce LAL. We see this issue as a test case for complicated problems that cut across multiple agencies and require attention to both nature and human health. An ocean solution Doctors began injecting patients with various solutions in the mid-1800s, but it was not until the 1920s that biochemist Florence Seibert discovered that febrile reactions were due to contaminated water in these solutions. She created a method for detecting and removing the substances that caused this reaction, and it became the medical standard in the 1940s. Known as the rabbit pyrogen test, it required scientists to inject intravenous drugs into rabbits, then monitor the animals. A feverish rabbit meant that a batch of drugs was contaminated. The LAL method was discovered by accident. Working with horseshoe crabs at the Marine Biological Laboratory at Woods Hole, Massachusetts, in the 1950s and ’60s, pathobiologist Frederik Bang and medical researcher Jack Levin noticed that the animals’ blue blood coagulated in a curious manner. Through a series of experiments, they isolated endotoxin as the coagulant and devised a method for extracting LAL from the blood. This compound would gel or clot nearly instantaneously in the presence of fever-inducing toxins. Academic researchers, biomedical companies and the U.S. Food and Drug Administration refined LAL production and measured it against the rabbit test. By the 1990s, LAL was the FDA-approved method for testing medicines for endotoxin, largely replacing rabbits. Producing LAL requires harvesting horseshoe crabs from oceans and beaches, draining up to 30% of their blood in a laboratory and returning the live crabs to the ocean. There’s dispute about how many crabs die in the process – estimates range from a few percent to 30% or more – and about possible harmful effects on survivors. Today there are five FDA-licensed LAL producers along the U.S. East Coast. The amount of LAL they produce, and its sales value, are proprietary. Bait versus biotech As biomedical LAL production ramped up in the 1990s, so did harvesting horseshoe crabs to use as bait for other species, particularly eel and whelk for foreign seafood markets. Over the past 25 years, hundreds of thousands – and in the early years, millions – of horseshoe crabs have been harvested each year for these purposes. Combined, the two fisheries kill over half a million horseshoe crabs every year. There’s no agreed total population estimate for Limulus, but the most recent federal assessment of horseshoe crab fisheries found the population was neither strongly growing nor declining. Conservationists are worried, and not just about the crabs. Millions of shorebirds migrate along the Atlantic coast, and many stop in spring, when horseshoe crabs spawn on mid-Atlantic beaches, to feed on the crabs’ eggs. Particularly for red knots – a species that can migrate up to 9,000 miles between the tip of South America and the Canadian Arctic – gorging on horseshoe crab eggs provides a critical energy-rich boost on their grueling journey. Red knots were listed as threatened under the Endangered Species Act in 2015, largely because horseshoe crab fishing threatened this key food source. As biomedical crab harvests came to equal or surpass bait harvests, conservation groups began calling on the LAL industry to find new sources. Biomedical alternatives Many important medicines are derived from living organisms. Penicillin, the first important antibiotic, was originally produced from molds. Other medicines currently in use come from sources including cows, pigs, chickens and fish. The ocean is a promising source for such products. When possible, synthesizing these substances in laboratories – especially widely used medications like insulin – offers many benefits. It’s typically cheaper and more efficient, and it avoids putting species at risk, as well as addressing concerns some patients have about using animal-derived medical products. In the 1990s, researchers at the National University of Singapore invented and patented the first process for creating a synthetic, endotoxin-detecting compound using horseshoe crab DNA and recombinant DNA technology. The result, dubbed recombinant Factor C (rFC), mimicked the first step in the three-part cascade reaction that occurs when LAL is exposed to endotoxin. Later, several biomedical firms produced their own versions of rFC and compounds called recombinant cascade reagents (rCRs), which reproduce the entire LAL reaction without using horseshoe crab blood. Yet, today, LAL remains the dominant technology for detecting endotoxins in medicine. The main reason is that the U.S. Pharmacopeia, a quasi-regulatory organization that sets safety standards for medical products, considers rFC and rCR as “alternative” methods for detecting endotoxins, so they require case-by-case validation for use – a potentially lengthy and expensive process. The FDA generally defers to the U.S. Pharmacopeia. A few large pharmaceutical companies with deep pockets have committed to switching from LAL to rFC. But most drug producers are sticking with the tried-and-true method. Conservation groups want the U.S. Pharmacopeia to fully certify rFC for use in industry with no extra testing or validation. In their view, LAL producers are stalling rFC