Yeast infections, caused by an overgrowth of Candida yeast, can be uncomfortable and distressing. While these infections are common and treatable, they can cause discomfort and disrupt daily life. If you suspect you have a yeast infection, fear not! Here we will discuss how to treat yeast infection and dive into the causes, symptoms, prevention, and various treatment options available to help you find relief and recovery from this bothersome condition. Understanding Yeast Infections What is a Yeast Infection? A yeast infection, also known as candidiasis, is a common fungal infection that affects people of all genders. It typically occurs in warm and moist areas of the body, such as the vagina, mouth, or skin folds. Candida yeast is naturally present in the body, but an overgrowth can lead to uncomfortable symptoms. Common Symptoms Recognizing the signs of a yeast infection is essential for prompt treatment. Common symptoms include vaginal itching, burning, redness, and white, cottage cheese-like discharge in women. Men may experience itching, redness, and irritation on the penis. Oral yeast infections (thrush) can cause white patches on the tongue, inner cheeks, or throat, making swallowing difficult. Preventive Measures Maintain Good Hygiene Practicing good hygiene is a crucial step in preventing yeast infections. For women, this includes washing the genital area with mild, unscented soap and water and avoiding the use of douches or scented feminine products, as they can disrupt the natural balance of vaginal flora. Wear Breathable Clothing To prevent excessive moisture buildup, choose loose-fitting, breathable clothing, especially in the genital area. Avoid tight-fitting underwear or pants, as they can create an environment conducive to yeast overgrowth. Balanced Diet Maintaining a balanced diet that is low in sugar and refined carbohydrates can help prevent yeast infections. High sugar intake can contribute to yeast overgrowth, so focus on consuming whole grains, vegetables, lean proteins, and probiotic-rich foods like yogurt. (Credit: Depositphotos) Over-the-Counter Treatments Antifungal Creams and Suppositories Over-the-counter antifungal creams and suppositories are commonly used to treat yeast infections. They contain active ingredients such as miconazole, clotrimazole, or tioconazole, which help to eradicate Candida yeast and alleviate symptoms. Follow the instructions carefully and complete the full course of treatment to ensure complete recovery. Vaginal Antifungal Tablets Vaginal antifungal tablets are another effective option for treating yeast infections. These tablets are inserted into the vagina using an applicator and work to clear the infection from within. Like creams and suppositories, be sure to complete the full course of treatment to achieve the best results. Natural Remedies Probiotics Probiotics are beneficial bacteria that can help restore the balance of the vaginal flora, which is essential in preventing and treating yeast infections. Incorporate probiotic-rich foods like yogurt or take oral probiotic supplements specifically formulated for vaginal health. Tea Tree Oil Tea tree oil possesses natural antifungal properties and may help combat yeast infections. Dilute a few drops of tea tree oil with a carrier oil like coconut oil and apply it to the affected area, but avoid applying it directly to the vaginal area. (Credit: Depositphotos) Seeking Medical Attention Recurrent or Severe Infections If you experience recurrent yeast infections (more than four per year) or severe symptoms that do not improve with over-the-counter treatments, it’s essential to seek medical attention. A healthcare professional can properly diagnose the infection and recommend appropriate treatments or investigations if necessary. Those With Chronic Health Conditions For those who are prone to recurrent yeast infections or have chronic health conditions that make them more susceptible, a proactive approach to managing these infections is vital. It’s essential to work closely with a healthcare professional to identify any underlying health issues that may contribute to repeated infections. Conditions such as diabetes, weakened immune systems, and hormonal imbalances can increase the risk of yeast overgrowth. By addressing these underlying factors, healthcare providers can develop a personalized treatment plan to effectively manage and prevent future occurrences. Importance of Finishing Treatment One crucial aspect of managing yeast infections is understanding the importance of finishing the prescribed treatment, even if symptoms improve. Stopping the medication prematurely may allow the yeast to regrow and cause a relapse. It is equally important to adhere to the recommended dosage and follow the instructions provided by the healthcare professional or the product label. Avoid using over-the-counter antifungal treatments for self-diagnosed infections, as they may not effectively target the specific type of yeast present, leading to incomplete recovery. Lifestyle Factors To further reduce the risk of yeast infections, pay attention to lifestyle factors that can impact yeast overgrowth. For instance, reduce stress levels through relaxation techniques like meditation and regular exercise, as stress can weaken the immune system and contribute to infections. Moreover, avoid activities that can introduce bacteria or disrupt the vaginal flora, such as using scented products, excessive douching, or engaging in unprotected sexual activity. Adopting a holistic approach that combines healthy lifestyle habits with medical treatments, you can effectively manage and reduce the likelihood of yeast infections, promoting overall vaginal health and well-being. Remember, if you have any concerns or questions about yeast infections, consult a healthcare professional for proper evaluation and guidance. (Credit: Depositphotos) Conclusion Yeast infections are common, but they can cause considerable discomfort and disrupt daily life. Understanding the symptoms and taking preventive measures is crucial in reducing the likelihood of infection. Over-the-counter treatments and natural remedies can provide relief and facilitate recovery in mild cases. However, if symptoms persist or worsen, seeking medical attention is essential for proper diagnosis and treatment. With the right approach, you can effectively manage yeast infections and restore comfort and well-being to your life. Remember, maintaining good hygiene, a balanced diet, and proactive measures can go a long way in preventing future occurrences.
Author: medicalviseAdmin
Grammy-winning singer Tori Kelly remained hospitalized in an intensive care unit on Monday after collapsing the night before while out at a Los Angeles restaurant with friends. Kelly, 30, was being treated for blood clots around her lungs and in her legs, and doctors were working to determine whether they were also around her heart. Advertisement Her condition is “really serious,” a source told TMZ, which first reported the incident. Tori Kelly attends a Special Screening of Universal Pictures’ “The Super Mario Bros. Movie” at Regal LA Live on April 01, 2023 in Los Angeles, California. (Amy Sussman/Getty Images) The singer was dining in downtown L.A. when she noted her heart was beating very rapidly, TMZ reported. She passed out “for a while” shortly afterward, the source said, and has been in and out of consciousness ever since. Advertisement Her friends took her to Cedars-Sinai Medical Center, the city’s premier hospital, rather than calling an ambulance that would have taken her elsewhere, the outlet reported. Kelly won two Grammys in 2019 and earned Billboard’s Women in Music Breakthrough Artist Award in 2015. Her most recent tour was cut short by the COVID pandemic, and she told People in March that she was looking forward to getting back out on the road. She recently released “Missin u,” her first solo single in about three years. The musician started singing and performing at age 12, appearing on the television show “America’s Most Talented Kid” and signing with Geffen Records. She started posting YouTube videos two years later and then in 2010 got as far as “Hollywood Week” in her audition for the ninth season of “American Idol,” falling short before the “Top 24.” Her 2015 hit “Nobody Love” put her on the map, but a 2016 Grammy loss to Meghan Trainor pushed her to switch to gospel. In 2019 she won both the Best Gospel Album Award, for “Hidden Place,” and Best Gospel Performance/Song, for “Never Alone.” The switch was all about “taking a step back and realizing, you know, I want to do a project that’s really close to my heart and something I’m really passionate about,” she told the Daily News backstage after her Grammy win. “The fact that it got this response and got nominated for two Grammys is insane. I’m I just so honored and so thankful.”
July 24, 2023 — Allegheny General Hospital (AGH), the flagship academic medical center of Allegheny Health Network (AHN), announced today it has once again received the Mitral Valve Repair Reference Center Award from the American Heart Association (AHA) and the Mitral Foundation for a demonstrated record of superior clinical outcomes resulting from evidence-based, guideline-directed degenerative mitral valve repair. This is the third consecutive year AGH and its AHN Cardiovascular Institute team have been recognized as a Mitral Valve Repair Reference Center since the recognition was established in 2019, placing AHN’s program among the most elite nationwide. To date, only 21 facilities have earned this award across the country and AGH remains the only hospital to receive this recognition in Pennsylvania. “This award recognizes the commitment of our clinicians and caregivers who provide the highest levels of care to our patients, year after year,” said Walter E. McGregor, MD, lead surgeon of the AHN mitral valve program and director of AHN cardiac surgery at AHN Cardiovascular Institute. “On behalf of the entire Network, I want to extend my sincere gratitude to their tireless work that upholds the AHN Cardiovascular Institute’s longstanding legacy of clinical excellence.” The mitral valve is in the left side of the heart and works to keep blood flowing properly in one direction from the left atrium to the left ventricle. When the valve doesn’t work correctly, allowing blood to flow backward, the heart can’t pump enough oxygenated blood for the body. Symptoms of mitral valve regurgitation often include fatigue and shortness of breath. Mitral valve repair is considered the gold-standard therapy for degenerative mitral valves and is generally preferred over mitral valve replacement since valve repair is associated with improved survival and fewer long-term complications. Valve replacement with a bioprosthetic or mechanical valve typically has higher five-to-ten-year complication rates compared to repair. “We are pleased to recognize Allegheny General Hospital for their commitment to patients who need mitral valve repair,” said Robert O. Bonow, MD, professor of cardiology at Northwestern University and past president of the American Heart Association. “Choosing the right hospital for heart surgery is one of the most important health care decisions that patients and their referring physicians must make to ensure best outcomes. The Mitral Valve Repair Reference Center award identifies hospitals with excellent processes and outcomes and gives patients and cardiologists the information necessary to make these important decisions when mitral valve surgery is required.” The Mitral Valve Repair Reference Center Award was developed to identify, recognize and promote the nation’s recognized medical centers for mitral valve repair surgery. AGH earned the award for demonstrating adherence to evidence-based treatment guidelines as well as an ongoing commitment to reporting and measuring quality and outcome metrics specific to mitral valve repairs. “This such a meaningful designation as it is contingent on superb outcomes — 95% repair rate and less than 1% mortality — in a high volume of patients and verified by the AHA,” said Stephen Bailey, MD, cardiothoracic surgeon and Chair of AHN Cardiovascular Institute. “We’re incredibly proud of today’s recognition as it further establishes our program as a nationally recognized leader in managing and treating complex cardiovascular disease.” For more information: www.ahn.org
The 30-year-old singer reportedly collapsed while out to dinner with friends. LOS ANGELES — Grammy-winning singer Tori Kelly was rushed to the hospital after collapsing and is being treated for blood clots, multiple media outlets reported Monday. According to TMZ, which first reported the incident, Kelly was out to dinner in Los Angeles with friends on Sunday night when she fainted after experiencing a racing heartbeat. She was reportedly “out for a while” after collapsing and friends took her to the hospital. Doctors found blood clots in her legs and lungs, and were working to determine if there are any clots around her heart, TMZ reported. The 30-year-old singer is reportedly in and out of consciousness. Kelly first gained recognition as a teenager through her videos on YouTube, and made it through to Hollywood Week of the ninth season of American Idol when she was 16 years old. She was nominated for Best New Artist at the 2016 Grammy Awards and later won two Grammys in 2019 for her second album “Hiding Place,” in the categories of Best Gospel Album and Best Gospel Performance/song. She voiced the character Meena in the animated films “Sing” and “Sing 2.” This is a developing story. Check back for updates. RELATED: Elton John, Scorsese and more friends and admirers of Tony Bennett react to his death RELATED: After nearly 30 years, there’s movement in the case of Tupac Shakur’s killing. Here’s what we know
#inform-video-player-1 .inform-embed { margin-top: 10px; margin-bottom: 20px; } #inform-video-player-2 .inform-embed { margin-top: 10px; margin-bottom: 20px; } By Cindy Allen Enid News & Eagle ENID, Okla. — Regulations for blood donation centers and plasma donation centers vary, and the chief medical officer for Our Blood Institute (OBI) told Enid Rotarians that for-profit plasma centers are contributing to a decrease in blood donations at nonprofit centers. Dr. Tina S. Ipe MD, MPH, said OBI is the sixth-largest blood center in the United States. OBI was created in 1977 when physicians felt there was a lack of blood supply and that patients needed access to blood. She spoke to Enid Rotary Club on Monday, July 24, 2023. Enid’s OBI serves 16 counties and services 11 hospitals. Ipe said OBI collects blood products from donors who are not compensated for donating blood. The blood products collected undergo rigorous FDA-required testing. “We have conversations with hospitals about the blood products they are receiving, help them manage inventory and also provide medical information to the hospitals that we serve,” Ipe said. Ipe said that the opening of a new plasma center in Enid has impacted blood donations OBI is receiving. “What we have noticed with the Parachute Plasma Center opening in Enid, we have not had the same collection numbers as we did previous to their opening. Starting in March, our blood collection numbers have decreased,” she said. Parachute opened in late February. Ipe said the community should be “concerned” that as blood collections numbers decrease, local hospitals won’t have the blood they need. She said the FDA prohibits blood donation centers from paying donors; however, FDA does not have the same limitation on plasma centers. That means plasma centers can pay for plasma. Plasma is the yellow liquid portion of blood that makes cells move through the body efficiently. Plasma is composed of water and other components. “It maintains the pressure within your blood vessels,” she said. “Without plasma, your blood vessels would collapse.” Blood donation centers also take plasma donations. “When you go in for a plasma donation at a blood center, we remove some portion of your plasma, and that plasma gets frozen and provided to patients in hospitals,” she said. The principal difference between a blood center and plasma center is that blood centers are nonprofit and plasma centers are for-profit. Ipe stressed that blood center donations go to local hospitals. She said FDA requirements are stringent and ensure the safety of the donation. She also gave statistics about the number of plasma centers in the U.S., which she said number around 1,500. Plasma has become a global business, she said, and the U.S. is one of five countries that compensates for donations. “Two-thirds of the plasma (globally) comes from the United States,” she said. “We do have better safety measures, donors that tend to be healthier than the rest of the world. Our regulations also make it easier for plasma centers to set up shop and allow for paid donations.” Ipe said some donors can make hundreds of dollars a month through for-profit plasma donation centers. She said being paid for plasma donations is attractive for those who are economically disadvantaged. She said plasma centers have become a lucrative business, and she provided statistics that show the United States is one of the largest collectors of plasma in the world; yet, the plasma does not go back to the U.S. She said much of the plasma is manufactured into medical products at pharmaceutical manufacturing companies outside the United States. Ipe said OBI is encouraging people to talk to state and federal lawmakers about ways to offset the negative impact plasma centers have on nonprofit blood donations centers, including increasing taxes on plasma centers, taxing plasma donors as generating income, increasing FDA regulations for plasma centers and enacting laws that would require a certain percentage of manufactured plasma be returned to the U.S. Parachute Plasma Center responds The Enid News & Eagle reached out to Parachute for comments regarding its plasma center donations and operations. Eva Anderson, marketing director for JoinParachute, said Parachute has 13 locations, mostly in Texas. Enid is the only Oklahoma location. “Donors are compensated for taking the time to donate,” Anderson said. She said that after the donation, the plasma is frozen on site to preserve its purity and freshness. “Once it goes through the testing, we send it out to a U.S.-based drug manufacturer,” she said. That manufacturer handles the fractionation where the plasma is made into medical products. She said all of Parachute’s production is done within the U.S. “Testing covers both safety of the donor as well as anyone receiving,” she said. “We test for all viral markers, any irregular antibodies. Before each visit, we check the donor’s protein and red blood cell levels. When donors come in for the first visit, they get a comprehensive physical. That’s another check to ensure they’re healthy and doing well.” As for where the plasma donations eventually go, Anderson said the U.S. is one of the only countries that compensates for donations. “We (U.S.) supply 70% of the global plasma for patients … since other countries are not compensating, (donors), they don’t have as much supply.” Community blood drive Tuesday OBI is hosting an Enid Community Challenge Blood Drive from 10 a.m. to 6 p.m. Tuesday, July 25, in the Stride Bank Center ballroom. Coffee Inclination will be serving drinks to donors and A Fuego Pizzeria Truck will be there to feed donors. Each donor also will receive a free T-shirt, a Chick-fil-A meal voucher and a ticket of their choice to Science Museum Oklahoma, Frontier City, or Hurricane Harbor. The first 100 donors to sign in will receive a free fold-up lawn chair. #inform-video-player-3 .inform-embed { margin-top: 10px; margin-bottom: 20px; }
The Arizona Diamondbacks are getting a breath of fresh air as starting pitcher Merrill Kelly is returning to the lineup Tuesday night against the St. Louis Cardinals, Arizona Sports‘ John Gambadoro reported. Manager Torey Lovullo said Kelly is back at Chase Field with the team after hitting the 15-day IL on july 27 with a blood clot in his leg. Lovullo did not definitively announce Kelly as the starter because the team will still have to make a move to get him back on the active roster after Monday’s game. “He’s here, feeling great and was up to 85 pitches in his last outing,” Lovullo told reporters pregame. “We spoke for a brief minute and he is really excited to be here and be ready to go. … It’s (Ryne) Nelson, TBA and Zac (Gallen). There is a really strong possibility the TBA will be Merrill Kelly.” Despite Lovullo’s hesitance to commit to Kelly, the blood clot has dissipated from his leg and all medicals have been passed, clearing the way for him to pitch. The D-backs manager said despite the team being filled with young talent, Gallen and Kelly bring a much-needed 1-2 punch in the rotation, something the team has been severely lacking as of late. “We have a 1A and 1B with Zac and Merrill. They pump out the innings, they make pitches, they keep us in games,” Lovullo said. “I love the youngsters that have been coming out, doing their job and helping us win baseball games, but Merrill and Zac give us a different taste, different color each day. Getting him back will be a big push for us.” Catch all the action as the D-backs take on the Cardinals at 6:40 p.m. on 98.7, the Arizona Sports app and ArizonaSports.com.
Consuming strawberries may promote cognitive function and improve cardiovascular risk factors
Daily strawberry consumption was linked to improved cognitive function, lower blood pressure and higher antioxidant capacity in a randomized clinical trial presented today at Nutrition 2023, the annual meeting of the American Society of Nutrition (ASN). The study was conducted at San Diego State University and builds on previous research demonstrating the cardiovascular, metabolic and cognitive health benefits of strawberries. The double-blind, placebo-controlled study was conducted in 35 healthy men and women, aged 66 to 78. The participants consumed 26 grams of freeze-dried strawberry powder, equivalent to two servings of strawberries daily, or a control powder for eight weeks each. Following strawberry consumption, cognitive processing speed increased by 5.2%, systolic blood pressure decreased by 3.6% and total antioxidant capacity significantly increased by 10.2%. Waist circumference decreased by 1.1% during both the control and intervention arms of the trial. While consuming the control powder, participants experienced increased serum triglycerides. This study demonstrates that consuming strawberries may promote cognitive function and improve cardiovascular risk factors like hypertension. We’re encouraged that a simple dietary change, like adding strawberries to the daily diet, may improve these outcomes in older adults.” Shirin Hooshmand, professor in the School of Exercise and Nutrition Sciences at San Diego State and principal investigator on the study Strawberries are a source of many bioactive compounds. In addition to providing 100% of our daily vitamin C needs, strawberries contain heart-healthy nutrients like folate, potassium, fiber, phytosterols and polyphenols. Previous clinical trials have connected strawberry consumption to improvements in several markers for cardiovascular disease, including reduced total and LDL cholesterol (TC) and lower blood pressure. The link between strawberry consumption and brain health has also been well explored in both clinical and population-based studies. Strawberries and pelargonidin, a biochemical primarily found in strawberries, were associated with a reduced risk of Alzheimer’s dementia in studies conducted at Rush University. Long-term observational studies, including the Health Professionals Study and the Nurses’ Health Study, found that strawberry consumers had lower rates of cognitive decline. American Society of Nutrition
Tori Kelly has been hospitalized and is getting treatment for severe blood clots, according to a report from TMZ. The publication reports that the 30-year-old Grammy winner was out to dinner with her friends in downtown Los Angeles on Sunday night when she passed out after saying that her heart was beating fast. She was then transferred to Cedars-Sinai hospital, where she is currently getting treatment in the ICU. According to TMZ, doctors discovered blood clots in Kelly’s lungs and legs and are working to see if there are any clots around her heart. Billboard has reached out to Kelly’s reps for confirmation and more information. Kelly, who is managed by SB Projects, signed to Epic Records earlier this year. The singer-songwriter unveiled her first single with the label, “Missin U,” and its Y2K-inspired music video in March. The song, which samples Craig David’s 2000 single “Fill Me In,” marked Kelly’s first new music since 2019’s Inspired by True Events and 2020’s A Tori Kelly Christmas. In 2019, she won best gospel album at the Grammys for her sophomore album Hiding Place and best gospel performance/song for “Never Alone.” Following the release of “Missin U,” Kelly told People that she’s excited to get back on the road. “I miss touring so much. I was actually on a world tour right as COVID was happening, and it was heartbreaking to have to cancel that,” she shared. “Since then, I haven’t been able to tour. That’s one of the most exciting things I’m looking forward to. I can’t give any details or anything yet, but I cannot wait just to see fans again and belt out these songs with them.”
The BDN Opinion section operates independently and does not set newsroom policies or contribute to reporting or editing articles elsewhere in the newspaper or on bangordailynews.com. Lisa Jarvis is a Bloomberg Opinion columnist covering biotech, health care and the pharmaceutical industry. Even as COVID has faded into the background for most of the public, our curiosity about the virus’s idiosyncrasies hasn’t waned. Why does one member of a household suffer a hacking cough but another not even a sniffle? Why does long COVID afflict some and not others? A cluster of new studies suggests some of the answers lie in our genes. What scientists are learning could help them develop better vaccines in the future — either for new variants of COVID-19 or entirely new forms of SARS. Mild cases or asymptomatic infections have been relatively unstudied. Scientists’ focus on the sickest patients wasn’t just because of the urgency to save lives, but because it’s simply easier to study people in a controlled setting like a hospital. Collecting DNA, sequencing it and then tracking healthy people out in the community is an impossibly tall order. A team of researchers, led by the University of California, San Francisco’s Jill Hollenbach, found a clever way of getting around that problem by tapping into a group of people who had already given up their DNA: bone marrow donors. The team invited donors to participate in an ongoing project at UCSF called the COVID-19 Citizen Science Study. Hollenbach’s team recruited nearly 30,000 volunteers to download an app and, when they eventually tested positive for the virus, complete a questionnaire about their symptoms. Although they’ve been collecting data from that cohort for years now, this study was limited to the time before people were vaccinated so the results could be cleanly interpreted, Hollenbach said. They were looking for differences in a group of genes called HLA (short for human leukocyte antigen) that carry the recipes for proteins that help our immune cells distinguish between our own biological detritus and unwelcome invaders. The proteins show little pieces of viruses to our T-cells, which take this as an invitation to attack. Because T-cells have a long memory, they swoop in again fast the next time a similar virus invades. The researchers found that people who carried one copy of a version of a gene called HLA-B*15:01 were more than twice as likely to remain asymptomatic after being infected with COVID. And people who inherited two copies of the gene (one from each parent) were eight times more likely to never suffer symptoms. Hollenbach’s team found that this particular flavor of HLA is very good at recognizing garden variety coronaviruses, and the T-cells exposed to those were later very good at detecting important bits of SARS-CoV-2. In other words, people with this variant who also had, say, a common cold “have this kind of superpower” of managing their COVID infection to the point where they don’t have symptoms, she explains. “I think their findings are very exciting,” said Jean-Laurent Casanova, a Rockefeller University scientist who studies the relationship between our genes and susceptibility to infectious diseases. “It suggests that T-cells are involved in the early phase of SARS-CoV-2 infection, and that a strong T-cell response can blunt infection and prevent clinical manifestations.” @media ( min-width: 300px ){.newspack_global_ad.block_64c05594055dc{min-height: 100px;}} Another study, yet to be peer reviewed, offers genetic ties to the other end of the spectrum: when people suffer lingering symptoms. Researchers compared about 6,500 people with a long COVID diagnosis to nearly a million people without. People were 1.6 times more likely to develop long COVID if they had a variant in a gene called FOXP4. That same gene is also known to be a culprit in lung cancer and severe COVID. While these studies help explain the wide range of responses to the virus, many questions remain unanswered. For example, why were some people not just asymptomatically infected, but never infected? Casanova is interested in, say, that “health care worker without a mask in 2020 that has repeatedly tested negative, negative, negative. They’re seemingly resistant to infection and we think there’s a genetic basis for that.” His lab is currently analyzing some 2,000 genomes among that group to try to fish out the gene responsible. Scientists would also like to understand if there are genes involved in other, rarer situations, like the people whose infections cause brain swelling, or others that get a form of heart inflammation called myocarditis after getting the mRNA vaccines. @media ( min-width: 300px ){.newspack_global_ad.block_64c0559418de4{min-height: 100px;}} Like all science, understanding the genetic link to susceptibility is just pulling on the first thread. So much other work needs to be done to unravel the rest. Hollenbach’s findings about asymptomatic COVID, for example, should prompt more exploration into alternate approaches to vaccination. The existing vaccines all try to prevent infection altogether, but there could be merit in focusing on vaccines designed to take advantage of that memory T-cell response that seems to work so well for people with the right genetics. “Maybe you get infected, but manage it so quickly and effectively that you don’t experience illness,” she said. It is important to keep unraveling these mysteries. They teach us about better ways to address this virus, which we know is here to stay, and also contribute to the broader understanding of how genes shape the immune response. More articles from the BDN
Sepsis (Adobe Stock, unknown) A recent cost-consequence analysis in Critical Care Explorations has revealed that utilizing the IntelliSep Index (ISI) for early sepsis diagnosis in the emergency department (ED) is both more effective and less expensive in preventing mortality compared to procalcitonin. Christopher S. Hollenbeak, PhD, Department Head of Health Policy and Administration and Professor of Surgery and Public Health Sciences at Penn State University, answered questions from Infection Control Today® (ICT®) about the study. “Sepsis causes 270,000 deaths and costs $38 billion annually in the United States, “according to the authors of the study. “Most cases of sepsis present in the emergency department (ED), where rapid diagnosis remains challenging. The IntelliSep Index (ISI) is a novel diagnostic test that analyzes characteristics of WBC [white blood cell] structure and provides a reliable early signal for sepsis. This study performs a cost-consequence analysis of the ISI relative to procalcitonin for early sepsis diagnosis in the ED.” ICT: A summary of the key findings and why they are important. Christopher S. Hollenbeak, PhD, Department Head of Health Policy and Administration and Professor of Surgery and Public Health Sciences at Penn State University, (Photo courtesy of Cytovale) Christopher S. Hollenbeak, PhD: Our team performed a cost-consequence analysis to evaluate the health economics of using a new IntelliSep test to inform sepsis care in the ED. In this analysis, IntelliSep was compared to procalcitonin (PCT), a biomarker related to bacterial infection evaluated as a sepsis indicator and performed similarly to the standard of care. The study supported the hypothesis that using Intellisep as part of the sepsis diagnostic strategy may provide effective reductions in the clinical and financial burden of treating sepsis compared to a procalcitonin diagnostic strategy. The IntelliSep test could serve as an invaluable element of sepsis care by quickly and efficiently focusing care on those with the highest risk of sepsis while expediting the care of those with lower risk. ICT: What is the practical application of the key findings for infection preventionists from this study? CSH: The search for solutions and improvements in sepsis care has become increasingly complicated as the incidence of sepsis continues to rise due to increased awareness, changes in the population’s risk profile, such as increasing age and comorbidities, and the impact of the COVID-19 pandemic on pre-existing workforce shortages. Solutions that will safely reduce the cost of care without sacrificing outcomes will require addressing the many factors driving the soaring economic burden of the disease in this new, post-pandemic era of medicine. This study suggests that risk stratification informed by the IntelliSep test could improve survival for patients with sepsis as compared to that reported with PTC and do so with an expected cost of more than $800 less than that for PCT. This finding is important given that outcomes in sepsis have been proven dependent upon prompt recognition and action. ICT: What results surprised you, if any? CSH: One of the more surprising aspects of the study is that an IntelliSep-informed treatment process saves, on average, over $800 per patient tested while also providing a small mortality benefit. This indicates that the IntelliSep test may enable centers to decrease the economic burden of sepsis and achieve better clinical outcomes. And while the study design relies on many assumptions, it is a home run. ICT: What, if any, future research will there be related to this one CSH: Great question. This study approximates the health-economic outcomes of using the IntelliSep test to inform clinical care of potentially septic patients. The IntelliSep test recently received FDA Clearance. Applying the test in the care environment will offer another opportunity to capture clinical and financial outcome information and add additional information to this work. ICT: Is there anything else that you would like to add? CSH: In our evaluation, the IntelliSep test showed that using the test to inform sepsis care is clinically and economically superior to a strategy informed by PCT. This performance is encouraging, given that the test can be performed in under 10 minutes and utilizes whole blood from a standard EDTA draw. Given its performance and fit within hospital workflows, the trial represents a promising new development in managing sepsis patients.